摘要
脑内免疫细胞小胶质细胞有两种极化状态M1和M2。M2状态可吞噬β-淀粉样蛋白、防止Tau蛋白过度磷酸化,还可清除部分病理产物。针刺发挥作用的机制可能与转变小胶质细胞的极化状态有关。
There are two phenotypes of microglia, M1 and M2. Microglia in M2 polarization may associate with the phagorytosis of be-ta-amyloid and inhibition of Tau hyperphosphorylation, as well as in other pathology. Electroacupuncture can impact the phenotypes of mi-croglia, which may play a role in the treatment for Alzheimer＇s disease.
作者
李珑
柳维林
王志福
陶静
陈立典
LI Long LIU Wei-lin WANG Zhi-fu TAO Jing CHEN Li-dian(College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China)
出处
《中国康复理论与实践》
CSCD
北大核心
2017年第7期779-782,共4页
Chinese Journal of Rehabilitation Theory and Practice
基金
福建省康复技术协同创新中心课题(No.755010017-协同)
关键词
阿尔茨海默病
小胶质细胞
极化
电针
综述
Alzheimer＇s disease
microglia
phenotypes
electroacupuncture
review
