尼麦角林联合高压氧治疗血管性痴呆患者对其认知功能的影响研究

Effect of Neemaline Combined With Hyperbaric Oxygen Therapy on Cognitive Function in Patients With Vascular Dementia

目的研究尼麦角林联合高压氧治疗血管性痴呆患者对其认知功能的影响。方法资料选取的102例VD患者作为研究对象,按照治疗方案的不同分为对照组与研究组,前者(46例)单纯行尼麦角林治疗,后者(56例)联合高压氧治疗,对比两组治疗效果。结果研究组治疗前MMSE评分为(16.42±2.51)分,治疗后(23.48±5.63)分,对照组分别为(16.73±3.46)分、(19.98±4.56)分,与治疗前比较,两组治疗后MMSE评分均提高,但研究组提高幅度较之对照组更大,比较差异均具有统计学意义(P<0.05);研究组治疗后ADL评分为(20.04±4.31)分优于对照组的(28.11±4.53)分(P<0.05)。结论 VD患者行尼麦角林与高压氧联合治疗,可有效改善其认知功能及日常生活能力。

Objective To study the effect of nicergoline combined with hyperbaric oxygen therapy on cognitive function in patients with vascular dementia. Methods 102 patients with VD were selected as the study subjects. According to the different treatment regimens, the patients were divided into control group and study group. The former （46 cases） was treated with neferatine and the latter （56 cases） was treated with hyperbaric oxygen therapy. The treatment effect was compared. Results The scores of M/vISE before treatment were （16.42±2.51）, after treatment （23.48±5.63） and control group were （16.73±3.46） and （19.98±4.56） respectively. Compared with the score before treatment, MMSE scores were improved, but the improvement rote of the study group was larger than that of the control group, the difference was statistically significant （P 〈 0.05）; after treatment the ADL score of the study group was （20.04±4.31）, which was significantly better than that of the control group （28.11±4.53） （P 〈 0.05）. Conclusion VD patients with nimergoline combined with hyperbaric oxygen therapy, can effectively improve its cognitive function and daily living ability.