摘要
目的观察小针刀疗法对膝骨关节炎患者的临床疗效以及对关节滑液IL-1、TNF-α表达的影响。方法将纳入实验的40例膝骨关节炎患者按随机方法分为两组,治疗组采用小针刀疗法;对照组采用膝关节腔内注射玻璃酸钠。观察患者治疗前后临床疗效、症状积分及可视化量表(WOMAC)评分改变,用Elisa法检测治疗前后关节滑液IL-1、TNF-α含量变化。结果 (1)临床疗效:治疗组总显控率优于对照组;(2)症状积分、WOMAC评分:两种方法均能改善患者的症状,且治疗组较对照组明显;(3)IL-1、TNF-α检测:两种方法均降低,且治疗组较对照组明显。结论针刀疗法能够通过降低关节滑液IL-1、TNF-α的含量到达改善临床症状的良性调节作用。
Objective To observe the clinical efficacy and the expression of IL-1 TNF-α in synovial fluid of the KOA by acupotomy. Methods 40 KOA patients were divided into treatment group and control group by random method. The clinical efficacy, symptom scores and WOMAC score before and after treatment were record, and the content of IL-1 and TNF-α in synovial fluid were detected by Elisa. Results （1）Effect： The treatment group was significant better than the control group in total effective. （2） Symptom score and WOMAC score： The treatment group was significant better than the control group. （3） IL-1, TNF-α detection indicators： The control group was better than treatment group. Conclusion Acupotomy can improve the benign regulatory effect of clinical symptoms by reducing the content oflL-1 and TNF-α in synovial fluid.
作者
朱定钰
吴明霞
ZHU Dingyu WU Mingxia(Acupuncture Department, Second People＇s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou Fujian 350003, Chin)
出处
《中国卫生标准管理》
2017年第15期86-88,共3页
China Health Standard Management
基金
国家自然科学基金(No.81373719)
