摘要
TUSC3基因在人类生长发育过程中起到重要作用,对于该基因的研究也逐渐增多.目前一些研究发现,TUSC3基因与离子转运、细胞粘附、增殖以及睾丸发育有密切关系.更重要的是,作为一个候选的肿瘤抑制基因,TUSC3基因沉默与乳腺癌、卵巢癌、胰腺癌等癌症的发生发展有密切联系.在多种肿瘤中发现TUSC3基因的缺失、重排以及异常甲基化,但其具体机制尚不完全明确.本文就TUSC3基因的研究进展作一综述.
TUSC3 gene plays an important role in human growth and development. TUSC3 gene is closely related to ion transport, cellular adherence, proliferation and testicular development. More importantly, TUSC3 gene silencing is associated with breast cancer, ovarian cancer, pancreatic cancer and other cancers as a candi- date tumor suppressor gene. Deletion, rearrangement and aberrant methylation of TUSC3 gene are discovered in a variety of tumors, but its specific mechanism is not completely clear. In this paper, the progress of TUSC3 gene is reviewed.
作者
周晓晗
顾页
林洁
ZHOU Xiao-Han GU Ye LIN Jie(Department of Pathology, Nanfang Hospital ＆ School of Basic Medicine, Southern Medical University, Guangzhou 510515, China)
出处
《转化医学电子杂志》
2017年第6期60-63,共4页
E-Journal of Translational Medicine
基金
国家自然科学基金(81672441)
广东省自然科学基金(2016A030313580)
广州市珠江科技新星专项计划(2012J2200044)
关键词
TUSC3
肿瘤
增殖
发育
离子转运
TUSC3
tumor
proliferation
development
ion transport
