非肌层浸润性膀胱癌治疗现状及进展

Research Progress on Non Muscle Invasive Bladder Cancer

大部分膀胱癌为非肌层浸润性癌,其标准治疗方法为经尿道膀胱肿瘤电切术,但术后复发率高,一部分患者会发展为肌层浸润性癌,对于具有复发和进展危险因素的患者采用膀胱内灌注免疫制剂或化疗药物治疗,膀胱内灌注标准药物无效的患者采用根治性膀胱全切术,新的治疗方法正在进行临床试验,如果有效,将提高非肌层浸润性膀胱癌的治疗效果。

The majority of bladder cancer diagnoses are non muscle invasive. Transurethral resec- tion of the bladder tumor is the current standard therapy for non muscle invasive bladder cancer. However, many patients have recurrent cancer and some will progress to muscle invasive disease. Intravesical immunotherapy or chemotherapy are used to patients with risks of recurrence and progression. Patients with no response to standard intravesical therapeutic agents will undergo radical cystectomy. Novel strategies currently being investigated ,if effective ,would improve the outcome of non muscle invasive bladder cancer.