60例非小细胞肺癌中IL-21R、MMP-2的表达及意义

Expression and Significance of IL-21R and MMP-2 in 60Cases with Non-small Cell Lung Cancer

[目的]探讨非小细胞肺癌(NSCLC)组织中IL-21R与MMP-2的表达及其在NSCLC增长和转移中的作用。[方法]检测并比较60例非小细胞肺癌组织以及60例正常肺组织中IL-21R、MMP-2的表达,比较其阳性表达率与NSCLC患者恶性生物学行为的关系,并进行相关性及预后分析。[结果]IL-21R、MMP-2阳性率在NSCLC中的表达显著性高于癌旁正常组织(P<0.05)。IL-21R与肿瘤直径有关,IL-21R和MMP-2的表达与淋巴结转移、组织分化、临床分期均相关(P<0.05)。多因素Logistic回归分析显示,IL-21R和MMP-2高水平表达、淋巴结转移、组织学分化、临床分期是NSCLC患者的独立预后因素。[结论]NSCLC中IL-21R表达和MMP-2表达与肿瘤恶性生物学行为有关,可作为肺癌预后的客观指标。

[Ohjective] To investigate the expression of interleukin-21 receptor IL-21R （IL-21R） and matrixmetalloproteinases-2（MMP-2） in non-small cell lung cancer （NSCLC） and its role in the growth and metastasis of NSCLC. [Methods] The expression IL-21R and MMP-2 in 60 cases with NSCLC and 60 cases of normal lung tissue were detected. The relationship between the posi- tive expression of IL-21R and MMP-2 and the biological features of NSCLC patients was com- pared and the correlation analysis was undertaken. [Results] The positive rate of IL-21R and MMP-2 in NSCLC were significantly higher than those in adjacent normal tissues, and the expres- sion of IL-21R and MMP-2 showed negative correlation （P〈0.05）. IL-21R was related to tumor diameter, and the expression of IL-21R and MMP-2 was related to lymph node metastasis,tissue differentiation and clinical stage（P〈0.05）. Multivariate regression analysis showed that IL-21R and MMP-2 highly expressed, lymph node metastasis,histological differentiation and clinical stage were independent prognostic factors in patients with NSCLC. [Conclusionl Expression of IL-21R and MMP-2 in NSCLC are related to the malignant biological behavior of the tumor, which can be used as an objective index for the prognosis of lung cancer.