Runx2和Slug在乳腺癌中的表达及意义

Expression of Runx2 and Slug in Breast Cancer and Its Significance

[目的]探讨Runx2和Slug在乳腺癌组织中的表达及临床意义。[方法]采用免疫组化法检测Runx2和Slug在105例乳腺浸润性导管癌和105例癌旁乳腺组织中的表达情况,分析其与乳腺癌临床病理特征间的关系。[结果]乳腺浸润性导管癌组织中Runx2及Slug的阳性表达率分别为69.52%(73/105)和42.86(45/105),显著性高于癌旁乳腺组织(P<0.05)。Runx2和Slug在乳腺浸润性导管癌中的表达均与ER呈负相关(r=-0.302,P<0.01;r=-0.368,P<0.01)。Runx2和Slug表达与乳腺癌的组织学分级、淋巴结转移和p TNM分期有关,而与患者年龄及肿瘤大小无关。[结论]Runx2及Slug可能成为预测乳腺癌恶性程度和评估乳腺癌患者预后的重要指标。

[Objective] To investigate the expression and clinical significance of Runx2 and Slug in patients with breast cancer. [Methods] The expression of Runx2 and Slug was detected in 105 cases of primary breast invasive ductal carcinoma（IDC） and 105 cases of para-tumor breast tissues by immunohistochemistry,and the relationship between expression of Runx2 and Slug with the clinical pathological features of breast cancer was evaluated. [Results] The positive expression rates of Runx2 and Slug in IDC were 69.52%（73/105） and 42.86%（45/105） respectively,which were higher than those in para-tumor breast tissues （P〈0.05）. The expression of Runx2 and Slug both negatively correlated with the expression of ER in IDC （r=-0.302 ,P〈0.01 ;1=-0.368 ,P〈0.01）. Furthermore ,Runx2 and Slug expression showed a significant relationship with histopathologic grade,lymph node metastasis and pTNM stage of IDC,but did not correlate with patients＇ age and tumor size. [ Conclusion ] Runx2 and Slug may be important factors to evaluate the malignant degree and assess the prognosis in patients with breast cancer.