期刊文献+

宫颈腺癌综合治疗后使用绝经激素治疗的进展

Progress on Menopausal Hormone Therapy in the Patients with Cervical Adenocarcinoma after Comprehensive Treatment
原文传递
导出
摘要 宫颈腺癌综合治疗后(手术和/或放疗后)卵巢功能降低甚至丧失,引起近期绝经症状及某些远期疾病,如高血压、冠心病、糖尿病及骨质疏松等,严重影响患者生活质量。绝经激素治疗能够有效缓解上述症状,显著提高生活质量,但其在宫颈腺癌患者的使用安全性问题上一直饱受争议。近年来随着相关临床试验的进展,该观点正在逐渐发生转变。 After comprehensive treatment (surgery and/or radiotherapy) of cervical adenocarcino- ma,ovarian function decreases or even gets lost,which cause the recent menopausal symptoms and some long-term diseases such as hypertension,coronary heart disease,diabetes and osteo- porosis,which seriously affect the patients' life quality. Menopausal hormone therapy effectively alleviates these symptoms, significantly improve the patient's life quality ,but its security in pa- tients with cervical adenocarcinoma has always been controversial. In recent years,with the progress of related clinical trials, this view is gradually changing.
出处 《肿瘤学杂志》 CAS 2017年第7期627-630,共4页 Journal of Chinese Oncology
关键词 宫颈腺癌 绝经综合征 绝经激素治疗 cervical adenocarcinoma menopausal syndrome menopausal hormone therapy
  • 相关文献

参考文献4

二级参考文献21

  • 1袁芳,王惠兰.激素替代疗法研究进展[J].医学综述,2005,11(1):50-52.
  • 2潘忠勉,李力,陈心秋,高琨,唐勇.雌激素替代治疗对生育期卵巢恶性肿瘤及宫颈癌患者预后的影响[J].中国实用妇科与产科杂志,2006,22(3):194-197. 被引量:11
  • 3顾美皎.激素替代疗法与妇科恶性肿瘤[J].中国实用妇科与产科杂志,1996,12(6):338-339. 被引量:9
  • 4刘景生主编.细胞信息与调控[M].北京:北京医科大学,中国协和医科大学联合出版社,1999.334~335.
  • 5Guzeloglu KO,Kayisli UA, Al-Rejjal R,et al. Regulation of PrEN (phosphatase and tensin homolog deleted on chromosome 10) expression by estradiol and progesterone in human endometrium[J]. J Clin Endocrinol Metab, 2003, 88: 5017-5026
  • 6Franke HR, Kole S, Ciftci Z, et al. In vitro effects of estradiol,dydrogesterone,tamoxifen and cyclophosphamide on proliferation vs.death in human breast cancer cells[J]. Cancer Lett,2003,190:113-118
  • 7Mabuchi S, Ohmichi M, Kimura A, et al. Estrogen inhibits paclitaxel-induced apoptosis via the phosphorylation of apoptosis signal-regulating kinase 1 in human ovsrian cancer cell lines [J]. Endocrinology, 2004,145:49-58
  • 8Syed V, Ho SM. Progesterone-induced apoptosis in immortalized normal and malignant human ovarian surface epithelial cells involves enbanced expression of FasL [J]. Oncogene,2003, 22: 6883-6890
  • 9Thongngarm T, Jenkins JK, McMurray RW. 7 Estrogen and prpgesterone differentially modulate cell cycling, apoptosis,and response to lipopolysaccharide in moncyte cell lines[J].Allergy Clin Immunol,2002,109(1)Suppl: S233
  • 10Li C,Samsioe G,Losif C.QuaLity of lifeinlong-time survivors of cervical cancer[J]. Mauaritas, 1999,32:95-102

共引文献22

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部