妊娠期糖尿病合并子痫前期的风险因素及预后分析

Risk factors and outcome analysis of pregnant woman with gestational diabetes mellitus combined with pre-eclampsia

目的 探讨妊娠期糖尿病（GDM）合并子痫前期（PE）发病的风险因素,观察孕妇的妊娠结局.方法 选择198例GDM合并PE孕妇作为实验组,以167例单纯GDM孕妇为对照组.收集并记录两组孕妇的临床资料与实验室数据,统计两组孕妇与围生儿并发症发生率.结果 实验组分娩孕周、胎儿体质量显著低于对照组（P均〈 0.05）,孕妇体质量、体质量指数显著高于对照组（P均＆lt;0.05）,实验组孕妇空腹血糖、总胆固醇、三酰甘油、尿酸指标显著高于对照组（P均＆lt;0.05）,实验组孕妇及围生儿的剖宫产、早产、产后出血、胎儿窘迫、FGR的发生率显著低于对照组,差异有统计学意义（P均＆lt;0.05）.结论 血脂与血糖代谢异常,血胆固醇与三酰甘油升高,空腹血糖异常是GDM孕妇并发PE的危险因素.因此,应积极监测控制GDM孕妇血脂与血糖可降低PE的发生率,改善GDM孕妇与新生儿的围生期结局.

Objective To evaluate the risk factors and outcome in pregnant woman with gestational diabetes mellitus（GDM） combined with pre-eclampsia.Methods One hundred and nity-eight cases of GDM combined with PE pregnant were selected as the experiment group.A total of 167 cases of GDM were selected as the control group.The incidences of complications of the two groups and laboratory data were recorded.Results The gestational age, birth weight of the experiment group were significantly lower than those of the control group （P〈 0.05）.The maternal weight, body mass index （BMI） of the experiment group were significantly higher than those of the control group （P〈 0.05）.The fasting blood glucose （FBG）, total cholesterol （TC）, triglyceride （TG）, uric acid （UA） of experiment group were significantly higher（P〈 0.05）.The perinatal children cesarean section, premature delivery, postpartum hemorrhage, fetal distress, FGR incidence of the experimental group were significantly lower than the control group, the differences were significant （P〈 0.05）.Conclusions Lipid and glucose metabolic disorders, increased blood cholesterol and triglycerides, abnormal fasting glucose are risk factors in pregnant woman with gestational diabetes mellitus combined with pre-eclampsia.Therefore, actively monitor and control blood lipids and blood glucose in GDM, can reduce the incidence of PE and improve the perinatal outcome in pregnant women with GDM and newborns.