罗红霉素治疗老年梅毒患者临床疗效及其对患者血清抗核抗体的影响

Clinical effect of roxithromycin in the treatment of senile syphilis and its effect on serum antinuclear antibody

目的探讨罗红霉素在老年梅毒患者中治疗效果及对血清抗核抗体(ANA)影响。方法选取2015年3月—2017年1月我院诊治老年梅毒患者80例随机分为罗红霉素组40例和青霉素组40例,比较两组患者疗效及对ANA影响。结果罗红霉素组和青霉素组疗效比较无显著差异[92.50%vs.97.50%,P<0.05]。治疗前及治疗后3月两组患者ANA阳性率、RPR阴性率比较无统计学意义(P>0.05);同组间比较,治疗后3月两组患者ANA阳性率均显著低于治疗前,RPR阴性率显著高于治疗前(P<0.05)。结论罗红霉素在老年梅毒患者中治疗具有显著临床疗效,可显著降低ANA水平,可作为青霉素过敏替代治疗药物。

Objective ： To investigate the therapeutic effect of roxithromyein in elderly patients with syphilis and its effect on serum antinuelcar antibody（ANA）. Methods：Select 80 case of aged syphilis patients in our hospital during Mar, 2015 Jan,2017 ,randomly divide them to roxithromycin group （roxithromycin treatment ,40 cases） and penicillin group （penicil- lin treatment ,40 cases）, compare the two groups of patients in efficacy and effect on ANA. Result ：Roxithromycin group and penicillin group, the effect was no significant difference[92.50% vs. 97.50% ,P 〈 0. 05 ]. There was no significant differ- ence in ANA positive rate and RPR negative rate between the two groups before and after treatment （ P 〉 0. 05 ）. The posi- tive rate of ANA in the two groups was significantly lower than that before treatment, RPR negative rate was significantly higher than before treatment （P 〈 0. 05 ）. Conclusion： Roxithromycin in the treatment of elderly patients with syphilis has a significant clinical etticacy, can significantly reduce the level of ANA, can be used as penicillin allergy replacement therapy.