三种色谱法分离手性药物的研究进展

The Research Progress of the Separation of Chiral Drugs by Three Chromatographic Methods

由于手性药物的生物活性、药理作用、代谢过程、毒性有着很大的差异。因此,对于合理用药,手性药物的分离具有很大的社会价值和经济价值,也成为了国内外上的研究热点。在常见的手性拆分方法中,色谱法以分离效果好、简单便捷的优点占据了重要位置。简介了手性药物的研究情况,并且综述了三种色谱法拆分手性药物的研究进展,并对其发展进行了展望。

There are great differences of the biological activity, pharmacological action, metabolic process and toxicity of chiral drugs. Therefore, the separation of chiral drugs has great social value and economic value, and has become research hotspots at home and abroad. In the common methods of chiral separation, chromatography is an important place with good separation effect and simple. The situation of chiral drugs were introduced, and the research progress of the separation of chiral drugs by three chromatographic methods was reviewed. The development was prospected.