盐酸美金刚在改善帕金森痴呆患者认知功能和日常生活能力的疗效观察

Observation of the Curative Effect of Memantine Hydrochloride in Improving Cognitive Function and Daily Life Quality of Patients with Dementia Parkinson

目的分析帕金森痴呆患者应用盐酸美金刚治疗的临床价值,且观察其对患者日常生活能力与认知功能造成的影响。方法选取2014-05—2016-05间阳春市人民医院神经内科的患帕金森痴呆的70例患者,随机分为两组:参考组患者35例,予多巴丝肼与盐酸多奈哌齐联合治疗;治疗组患者35例,予多巴丝肼与盐酸美金刚联合治疗。观察两组患者治疗前、后的日常生活能力与认知功能变化。结果治疗后4周、8周及16周时治疗组的MMSE量表与Mo CA量表评分均较参考组更高(P<0.05);治疗后治疗组的临床满意率较参考组显著更高(P<0.05)。结论盐酸美金刚能够有效改善帕金森痴呆患者的认知功能,提高患者的日常生活能力,值得临床借鉴推广。

Objective To analyze the clinical application value of Parkinson hydrochloride memantine for the treatment of dementia patients,and to observe its impact on activities of daily living（ ADL） and cognitive function. Methods 70 patients in the hospital from May,2014 May to May,2016 having Parkinson with Dementia were randomly divided into 2 groups： 35 cases in control group were treated with Levodopa and Benserazide Hydrochloride combined with donepezil,and 35 cases in the treatment group were treated with levodopa and Benserazide and Memantine Hydrochloride. ADL and cognitive function of the 2 groups before and after treatment were observed. Results After treatment of 4 weeks,8 weeks and 16 weeks,MMSE scale and Mo CA scale scores of treatment group are significantly higher than the control group（ P〈0. 05）; After treatment,the clinical satisfactory rate of the treatment group is significantly higher than the control group（ P〈0. 05）. Conclusion Memantine hydrochloride can effectively improve the cognitive function of Parkinson＇s dementia patients,and improve the ability of daily life of patients. So it is worthy of clinical promotion.