2006至2015年归因于石棉肺疾病负担的探索性分析

Exploratory analysis on burden of disease attributable to asbestosis from 2006 to 2015

目的 分析2006至2015年我国归因于石棉肺疾病负担的水平及变化趋势.方法 收集2006至2015年的新发石棉肺职业病报告数据,结合2015年全球疾病负担（GBD）研究中的伤残权重、缓解率,采用DisMoD-MR 2.1软件估算平均病程和发病年龄,使用GBD估算方法计算伤残损失寿命年（YLD）、早死损失寿命年（YLL）和伤残调整寿命年（DALY）,分析归因于石棉肺的疾病负担水平及其随时间变化的趋势.结果 我国2006至2015年归因于石棉肺YLD总负担为39632人年,其中男性累计YLD为19271人年（占48.62%）,女性累计YLD为20361人年（占51.38%）.我国2015年归因于石棉肺DALY由2006年的8623.76人年下降至6436人年;其中,2015年YLD为6436人年,YLL为0人年;2006年YLD为8550人年,YLL为73.76人年.2006年归因于石棉肺造成的DALY最大（8623.76人年）,2008年造成的DALY最小（1558人年）,2008至2015年间DALY呈波动上升趋势.男性与女性DALY变化趋势趋于一致.结论 2006至2015年归因于石棉肺的疾病负担水平女性高于男性,YLD疾病负担总体呈波动上升趋势.

Objective To analyze the levels and trends of the burden of disease attributable to asbestosis from 2006 to 2015. Methods Theincidence of asbestosis from 2006 to 2015 was used for calculation , with data of disability weight and remission rate from Global burden of disease study 2015 （GBD 2015） and DisMoD-MR 2.1 software for the calculation of duration and age of year onset. The reference template of GBD was adopted to calculate disability adjusted life year（DALY）, year of life lost（YLL） and year of lived with disability（YLD） value in order to analyze the level and changing trend of burden of disease attributable to asbestosis. Results A total YLD attributable to asbestosis during 2006 and 2015 in China was 39632. The YLD burden of female was more severe than male, which accounted for 20361 in female and 19271 in male. In 2015, DALY attributable to asbestosis decreased from 8623.76 in 2006 to 6436. Among that, in 2015, YLD was 6436 and YLL was 73.76. 2006 had a highest level of DALY and 2008 had the lowest level of DALY, which accounted for 8623.76 in 2006 and 1558 in 2008. DALY during 2008 and 2015 had a fluctuant increase, and both male and female had such trend. Conclusion The level of burden of disease attributable to asbestosis is higher in male than in female during 2006 and 2015. Between 2006 and 2015, burden of disease attributable to asbestosis has a fluctuant increase trend.