益气活血方对慢性脏病合并高血压患者的临床疗效研究

Qi-tonifying and Blood-Activating Formula's Clinical Efficacy in Patients with Chronic Disease with High Blood Pressure

目的:探讨益气活血方对慢性肾脏病合并高血压患者生活质量的影响。方法:采用随机、单盲、平行、对照研究设计,选取2013年1月至2015年6月大连大学附属中山医院中医科、肾内科收治住院的慢性肾脏病合并高血压患者93例,随机分为2组:治疗组48例,常规治疗的基础上加用益气活血方;对照组44例,常规治疗。检测治疗前后患者血清肌酐(SCr)、尿素氮(BUN)、胱抑素C(Cys C)水平,并计算内生肌酐清除率(CCr)。检测血压达标率,评价患者的临床疗效。结果:治疗后治疗组SCr、BUN、Cys C水平明显低于对照组,P<0.05;CCr水平明显高于对照组,P<0.05。治疗组血压达标率为83.6%,对照组为65.3%。2组的血压达标率比较,P<0.05。治疗组有效率为83.33%,对照组为63.64%,2组比较P<0.05。结论:益气活血方可以改善慢性肾脏病合并高血压患者的临床疗效。提高血压达标率。

Objective：To explore the Qi-tonifying and Blood-Activating Formula＇s effect on the quality of life of hypertension patients with chronic kidney disease.Methods：We adopted a random,single blind,parallel and control study design,in which 93 cases of patients with chronic kidney disease with hypertension were randomly divided into two groups：treatment group （48 cases,given Qi-tonifying and Blood-Activating Formula treatment with conventional treatment） and the control group （44 cases,given conventional treatment）.Test for serum creatinine （SCr） in patients with urinary inhibition,urea nitrogen （BUN）,C （CysC） level was performed before and after treatment,and the endogenous creatinine clearance rate （CCr） was also calculated,as well as blood pressure and the clinical curative effect.Results：SCr,BUN,CysC levels of the treatment group after the treatment were significantly lower than the control group,（P 〈 0.05）;CCr level obviously is higher than the control group （P 〈 0.05）.Blood pressure passing rate of the treatment group was 83.6%,the control group 65.3%.And there was significant difference between the two groups （P 〈 0.05）.Treatment group＇s effective rate was 83.33 %,the control group 83.33 %,showing significant difference between the two groups （P 〈 0.05）.Conclusion：Qi-tonifying and Blood-Activating Formula can improve the clinical curative effect of patients with chronic kidney disease with hypertension and regulate patients＇ blood pressure.