骨松健骨方对绝经后骨质疏松症(肝肾阴虚证)患者骨密度及骨代谢指标的影响

Effects of Gusong Jiangu Decoction on Bone Mineral Density and Bone Metabolism Markers in Postmenopausal Osteoporosis of Liver-Kindey Yin Deficiency Type

目的:研究骨松健骨方对绝经后骨质疏松症(肝肾阴虚证)患者骨密度及骨代谢指标的影响。方法:收集河南省洛阳正骨医院骨质疏松科门诊2013年9月至2014年9月参与临床观察的试验病例60例,采用随机、平行对照研究方法,治疗组30例,服用骨松健骨方;对照组30例,服用左归丸。观察治疗后2组病例骨密度及骨代谢指标BALP、β-CTX的改善情况。结果:治疗前后比较,骨松健骨方可有效抑制骨吸收(P<0.05);防止骨密度下降,总有效率为89.29%。治疗组与对照组比较,骨松健骨方疗效优于左归丸(P<0.05)。结论:骨松健骨方可有效抑制骨吸收、防止骨密度下降。

Objective：To investigate the effects of Gusong Jiangu Decoction on the bone mineral density and bone metabolism markers for patients with postmenopausal osteoporosis of liver and kidney yin deficiency syndrome.Methods：A total of 60 patients who participated in the clinical observation in osteoporosis department in Luoyang Orthopedic Hospital of Henan Province were collected during 2013 September to 2014 September divided into two groups with 30 patients in each group.Patients in experiment group were treated with Gusong Jiangu Decoction,while patients in thc control group contained took Zuoguiwan Capsule.T bone mineral density and bone metabolism markers,including BALP and β-CTX,were investigated after the treatment.Results：Gusong Jiangu Decoction inhibited the bone absorption efficiently （P 〈 0.05） and prevented the decrease of bone mineral density.The total effective rate was 89.29%.Compared the control group,the effects of Gusong Jiangu Decoction was better than that of the Zuoguiwan capsule for postmenopausal osteoporosis of the liver-kidney yin deficiency type （P 〈 0.05）.Conclusion：Gusong Jiangu Decoction may inhibit the bone absorption and prevent the decrease of bone mineral density.