基于循证医学的重症肌无力中医文献质量评价研究报告

Evaluation of TCM literature quality on Myasthenia Gravis Based on Evidence-Based Medicine

目的:对现代中医治疗重症肌无力的文献进行检索和文献质量评价,为重症肌无力中医临床诊疗指南的制修订提供循证证据及参考。方法:以计算机检索为主方法,检索中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普数据库、Pubmed等数据库,采用Noteexpress2.8软件进行文献剔重,纳入中医治疗重症肌无力文献,采用改良Jadad量表、AMSTAR量表、MINORS条目评价量表进行文献质量评价,采用"基于证据体的临床研究证据分级参考建议"对文献证据等级进行分级。结果:最终纳入372篇文献,经过文献质量评价,所纳入的文献质量均不高。文献证据推荐级别方面,推荐级别为IV,104篇,推荐级别为V,268篇。结论:重症肌无力中医诊疗指南的制修订尚需高质量、大样本的随机对照研究,与此同时,需要更科学合理地利用中医名家临床经验。

Objective：To search literature about TCM treatment for myasthenia gravis and to evaluate literature quality,providing evidence and reference for TCM clinical diagnosis and treatment guideline of myasthenia gravis.Methods：Literature was retrieved by computer search and manual search in China Academic Journal （CNKI）,Chinese Biomedical Literature Database （CBM）,VIP database,Pubmed and other databases.Noteexpress 2.8 software was used for reduplication of literature of myasthenia gravis.Modified Jadad scale,AMSTAR scale and MINORS entry literature quality assessment rating scale were applied for literature quality evaluation.Literature was graded according to Reference for Evidence-Based Clinical Evidence Grading.Results：A total number of 372 journals were finally included.The quality literature was not high after assessment.The recommended grading level was IV with a total number of104 articles and 268 articles were recommended for grade V.Conclusion：TCM clinical diagnosis and treatment guidelines for myasthenia gravis still need to be highly developed and revised.Randomized and controlled studies with large sample are further needed.Scientific and appropriate use of experience from famous physicians is also required at the same time.