黄芪注射液对慢性心力衰竭疗效及对MDA、HO-1、NO的影响

Effects of Astragalus Injection on Heart Failure Patients and MDA,HO-1 and NO

目的:观察黄芪注射液治疗慢性心力衰竭(CHF)患者的作用,并探讨其对丙二醛(MDA)、血红素加氧酶1(HO-1)、血管舒张因子(NO)的影响。方法:将60例CHF患者随机分为黄芪注射液组和对照组各30例。对照组常规使用吸氧、利尿、扩血管、强心,控制原发病和消除心衰诱因等常规治疗。黄芪注射液组在常规治疗的基础上,应用黄芪注射液治疗。观察临床疗效,测定左室功能指标。并检测两组治疗前后MDA、HO-1、NO的浓度。结果:黄芪注射液组总有效率达到93.33%,显著高于对照组的76.67%(P<0.05)。治疗前的6 min步行距离无明显差距,治疗后黄芪注射液组6 min步行距离是(693.83±23.70),显著高于对照组的(617.60±38.95)。治疗前的两组心功能参数差异无显著性,两组每搏出量(SV)、射血分数(EF)治疗后都显著增加(P<0.05);治疗后黄芪注射液组SV、EF显著高于治疗后对照组(P<0.05)。治疗前的两组MDA、NO、HO-1差异无显著性。与相应组的治疗前比较,治疗后两组MDA显著降低,NO与HO-1显著增加(P<0.05);治疗后黄芪注射液组MDA低于治疗后对照组,NO、HO-1高于治疗后对照组,差异具有统计学意义(P<0.05)。结论:黄芪注射液对CHF患者的心功能指标有明显改善作用,可能与其提高内源性抗氧化应激从而治疗CHF有关。

Objective：To observe the effect of Astragalus Injection in the treatment of chronic heart failure（CHF） patients and investigate its effect on the MDA,HO-1 and NO.Methods：Sixty patients with CHF were randomly divided into Astragalus Injection treatment group and control group with 30 cases in each.Control group received conventional therapy alone,whereas the Astragalus Injection treatment group was given Astragalus Injection treatment in addition.Observe the clinical curative effect,the determination of left ventricular function indicators.And detect the concentrations of MDA,HO-1 and NO of two groups before and after treatment.Results：The total effective rate of Astragalus Injection group reached 93.33%,significantly higher than the control group’s 76.67%（P〈0.05）.There was no significant difference in 6 min walking distance between two groups before treatment.The 6 min walking distance after treatment of astragalus injection treatment group was（693.83±23.70） m,significantly higher than the control group’s（617.60±38.95） m.There was no significant difference in SV or EF between two groups before treatment.SV and EF after treatment of Astragalus Injection treatment group was significantly higher than that of control group.There was no significant difference in MDA,NO or HO-1 between two groups before treatment.NO and HO-1 after treatment of Astragalus Injection treatment group were significantly higher than that of control group.And MDA was significantly lower than that of control group.Conclusion：Astragalus Injection on cardiac function in patients with CHF has significantly improved effect which may be related to the increased endogenous oxidative stress treat CHF.