仿真建模评估：多种方式均可以有效筛查结直肠癌

In simulation modelling, there are multiple ways to effectively screen for colorectal cancer

背景在目前已用于结直肠癌（CRC）筛查的方法中，仅乙状结肠镜检查和便隐血试验进行过随机对照试验评价。结肠镜检查和粪便免疫化学检测（FIT）是CRC筛查的2种常用方法，但如果获得随机对照试验的证据，至少还需要10年的研究。

Commentary on: Knudsen AB, Zauber AG, Rutter CM, et al. Estimation of Benefits, Burden, and Harms of Colorectal Cancer Screening Strategies: Modeling Study for the US Preventive Services Task Force. JAMA 2016;315(23):2595-609.[OpenUrl][1][CrossRef][2][PubMed][3] Of the available colorectal cancer (CRC) screening tests, only flexible sigmoidoscopy and faecal occult blood tests have been evaluated with randomized controlled trials (RCTs). Colonoscopy and faecal immunochemical tests (FITs) are commonly used for CRC screening, but RCT evidence will not be available for at least a decade. For its 2016 CRC screening recommendation, the US Preventive Services Task Force (USPSTF) commissioned the Cancer Intervention and Surveillance Modeling Network (CISNET) to analyse 8 screening tests, in 204 screening strategies in a hypothetical cohort of US 40-year-olds, using 3 different models. Each model simulated the adenoma-carcinoma sequence with … [1]: {openurl}?query=rft.jtitle%253DJAMA%26rft.volume%253D315%26rft.spage%253D2595%26rft_id%253Dinfo%253Adoi%252F10.1001%252Fjama.2016.6828%26rft_id%253Dinfo%253Apmid%252F27305518%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1001/jama.2016.6828&link_type=DOI [3]: /lookup/external-ref?access_num=27305518&link_type=MED&atom=%2Febmed%2F22%2F2%2F59.atom