免疫评分在结直肠癌中的研究进展

Research Progress of Immunoscore in Colorectal Cancer

结直肠癌是最常见的恶性消化系统肿瘤,近年来发病呈上升趋势。目前临床普遍采用TNM分期系统评估患者的预后,但该系统在临床实践中受到了挑战,主要表现在相同TNM分期系统患者的术后生存周期存在明显差异。近年来,免疫评分技术逐渐成为研究热点,该手段是通过将肿瘤微环境中的免疫细胞进行量化来预测肿瘤患者的生存周期。研究表明免疫评分能够更加准确地预测结直肠癌患者的临床预后,并且优于TNM分期和微卫星不稳定,在结直肠癌转移、术前放化疗的疗效评估中具有重要的作用。本文将对免疫评分在结直肠癌中的研究进展进行综述。

Colorectal cancer is the most common malignant tumor of the digestive system. In recent years,the incidence is on the rise. At present,TNM staging system is commonly used to evaluate the prognosis of patients clinically,but the system in clinical practice has been challenged. Patients in the same TNM stage may exhibit significantly discrepant survival after surgery. In recent years,immunoscore technology becomes a research hotspot. It predicts the survival period of cancer patients by the immune cell quantification in the microenvironment of the tumor. Studies have shown that immunoscore can predict the prognosis of colorectal cancer more accurately,and is superior to TNM classification and microsatellite instability; it also can evaluate the metastasis of colorectal cancer and the curative effect of radiotherapy and chemotherapy. In this article,the research progress of immunological evaluation in colorectal cancer is reviewed.