血清25羟维生素D与老年体位性低血压的相关性分析

Relationship between postural hypotension and serum 25 Hydroxy vitamin D in elderly patients

目的:探讨老年体位性低血压患者与血清25羟维生素D的关系。方法:回顾性分析546例合格患者的临床特点、血压、共患疾病、多重用药、认知功能和营养状态、基本和功能性的日常生活活动指数及一些实验室检测数据。采用放射免疫分析法检测血清25羟维生素D,并分析血清25羟维生素D与老年体位性低血压的相关性。结果:本研究体位性低血压在老年患者中发病率约27.5%,通过Logistic回归分析,在非校准模型中,25羟维生素D与体位性性低血压发生密切相关(OR=0.24;95%CI=0.12-0.73;P=0.004),而BADL、IADL也有相关性,P值均<0.05。结论:血清25羟维生素D缺乏,可能是老年体位性低血压发生发展的重要因素。

Objective：To investigate the relationship between serum 25 hydroxy vitamin D and elderly patients with orthostatic hypotension. Methods ： Retrospective analysis of 546 cases of qualified researchers, clinical features, blood pressure, comorbid diseases, polypharmaey, cognitive function and nutritional status, basic functions and of the index of activities of daily living and laboratory test data. Results ： We statistics of orthostatic hypotension incidence rate in elderly patients is 27.5% , by Logistic regression analysis, the non calibration model, 25 hydroxy vitamin D is closely related with orthostatic hypotension （OR =0.24, 95% CI = 0. 12-0. 73, P =0. 004）, while IADL and BADL are also related, P value is 〈 0. 05. Conclusion： Lack of serum 25 hydroxy vitamin D, may be an important factor in the development of elderly orthostatie hypotension.