增殖性脑血管病研究进展

Research Progress of Cerebral Proliferative Angiopathy

增殖性脑血管病(cerebral proliferative angiopathy,CPA)是一种原因不明的慢性缺血性脑血管疾病,是以颅内存在弥漫性密集增强的巨大血管网状空间,同时具有弥漫的增生血管供血为影像学特征表现的脑血管病。其在颅内动静脉畸形中占3.4%的比重,但临床表现及预后与动静脉畸形明显不同。其表现主要为癫痫、头痛和进行性神经功能缺损。由于该疾病直到近几年才被单独提出来,截至2016年4月6日,国内尚无文献对其报道。本文就CPA的病理、临床表现、影像学特点等最新研究做综述,旨在提高对CPA的认识,为未来更好地诊治做铺垫。

Cerebral proliferative angiopathy （CPA） is a chronic ischemic cerebrovascular disease for unknown reason. CPA is demonstrated as a diffuse network of densely enhancing vascular spaces and have angiographic hallmarks of diffuse proliferated vascular blood supply. It takes the share of 3.4% in arteriovenous malformations, but its clinical manifestations and prognosis are significantly different from the arteriovenous malformations. CPA is usually manifested with epilepsy, headache and progressive neurological deficits. Since CPA is just raised as independent issue in recent years, there are no domestic literature before April 6, 2016. This paper is to review recent studies based on the pathology, clinical manifestations, and imaging characteristics aiming at raising awareness of the CPA so as to pave the way for better diagnosis and treatment in the near future.