阿托伐他汀联合常规疗法治疗冠心病合并高脂血症的疗效观察

Observation on Efficacy of Atrovastatin Combined with Conventional Therapy in Treatment of Coronary Heart Disease Combined with Hyperlipemia

目的:探讨阿托伐他汀联合常规疗法治疗冠心病合并高脂血症的效果及安全性。方法:选择冠心病合并高脂血症患者156例作为研究对象,按奇偶分组法分为观察组和对照组,每组78例。对照组患者采用常规治疗方法,观察组患者在对照组的基础上加用阿托伐他汀,比较两组患者的治疗效果及临床指标改善情况,并观察不良反应发生情况。结果:治疗8周后,观察组患者的总有效率为94.87%(74/78),明显高于对照组的75.64%(59/78),差异有统计学意义(P<0.05)。治疗8周后,观察组患者总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平均较治疗前明显改善,且观察组患者改善情况明显优于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率的差异无统计学意义(P>0.05),且不良反应均较轻微,未经特殊处理后好转。结论:阿托伐他汀联合常规疗法治疗冠心病合并高脂血症效果较好,可明显改善患者血脂指标,且安全性较高。

OBJECTIVE： To probe into the efficacy and safety of atrovastatin combined with conventional therapy in treatment of coronary heart disease combined with hyperlipemia. MEHTODS： 156 patients with coronary heart disease combined with hyperlipemia were selected and divided into observation group and control group via parity grouping,with 78 cases in each group. The control group was given conventional therapy,while the observation group was given atrovastatin combined with conventional therapy,the therapeutic effect and improvement of clinical indices of two groups were compared,and the incidence of adverse drug reactions were observed. RESULTS： 8 weeks after treatment,the total effective rate of observation group was 94. 87%（ 74/78）,which was significantly higher than that of the control group（ 75. 64%,59/78）,with statistically significant difference（ P 〈0. 05）. 8 weeks after treatment,the total cholesterol,triacylglycerol,low density lipoprotein cholesterol and high density lipoprotein cholesterol of observation group were significantly improved compared with before treatment,and the improvements of observation group were significantly better than that of the control group,with statistically significant differences（ P 〈0. 05）.There was no significant difference in the incidence of adverse reactions between the two groups（ P 〉0. 05）,all the cases were mild and improved without special treatment. CONCLUSIONS： The efficacy of atrovastatin combined with conventional therapy in treatment of coronary heart dise6 ase combined with hyperlipemia is remarkable,which can significantly improve blood lipid indices,with high safety.