不同剂量米非司酮治疗子宫肌瘤的疗效观察

Observation on Efficacy of Different Doses of Mifepristone in Treatment of Patients with Hysteromyoma

目的:探讨不同剂量米非司酮治疗子宫肌瘤的临床疗效。方法:选取2013年5月—2016年5月绵阳市人民医院收治的子宫肌瘤患者174例作为研究对象,以随机数字表法分为A、B组,每组87例。A组患者给予米非司酮12.5 mg、1日1次,B组患者给予米非司酮25.0 mg、1日1次,两组患者均治疗3个月。观察两组患者的临床疗效、复发情况、子宫体积、子宫肌瘤体积及数目,比较两组患者雌二醇、孕酮水平及不良反应发生情况的差异。结果:两组患者痊愈率、好转率的差异无统计学意义(P>0.05);A组患者复发率明显高于B组,差异有统计学意义(P<0.05);治疗后,B组患者子宫体积、子宫肌瘤体积、子宫肌瘤数目明显小于A组,孕酮水平明显低于A组,差异均有统计学意义(P<0.05);两组患者雌二醇水平的差异无统计学意义(P>0.05)。B组患者不良反应发生率高于A组,差异有统计学意义(P<0.05)。结论:小剂量米非司酮治疗子宫肌瘤的疗效显著、不良反应较少,但停药之后极易复发,增大剂量后疗效未明显提高,但不良反应明显增多。

OBJECTIVE： To probe into the clinical efficacy of different doses of mifepristone in treatment of patients with hysteromyoma. METHODS： 174 patients with hysteromyoma admitted into Mianyang People＇s Hospital from May 2013 to May 2016 were extracted to be divided into group A and group B via the random number table,with87 cases in each. Patients in group A was given mifepristone 12. 5 mg,once a day. And group B received mifepristone25. 0 mg,once a day. The treatment course of two groups was 3 months. The clinical efficacy,recurrence,uterine volume,and volume and number of uterine fibroid of two groups were observed; differences of estradiol,progesterone and incidence of adverse drug reactions of two groups were compared. RESULTS： There was no statistical significance between two groups in the recovery rate,improvement rate（ P 0. 05）. The recurrence rate of group A was significantly higher than that of group B,with statistically significant difference（ P 0. 05）. After treatment,the uterine volume,volume and number of uterine fibroid in group B were significantly less than those in group A,yet the progesterone was lower than that in group A,with statistically significant difference（ P 〉0. 05）. There was no statistically significant difference between two groups in E2 level（ P 〈0. 05）. The incidence of adverse drug reactions of group B was significantly higher than that of group A,with statistically significant difference（ P 〈0. 05）.CONCLUSIONS： The efficacy of low dose mifepristone in treatment of patients with hysteromyoma is remarkable with few adverse drug reactions,yet it is easy to relapse after drug withdrawal; and the adverse drug reactions is increasing by the increase of dose,yet the efficacy has few changes.