BIM基因与儿童急性淋巴细胞白血病对糖皮质激素耐药的相关性

Association between BIM gene and glucocorticoid resistance in children with acute lymphoblastic leukemia

急性淋巴细胞白血病(ALL)是儿童时期最常见的恶性血液系统疾病。糖皮质激素作为ALL化疗方案中的主要用药,可通过多种途径诱导白血病细胞的凋亡,但仍有约10%的儿童ALL对糖皮质激素不敏感。研究发现糖皮质激素通过上调BIM基因表达介导ALL细胞的凋亡,BIM基因与儿童ALL对糖皮质激素耐药有关。本综述概括了近年关于儿童急性淋巴细胞白血病对糖皮质激素耐药相关研究,主要包括BIM基因及其表达产物在该过程中的作用。

Acute lymphoblastic leukemia（ALL） is the most common malignant hematological disease in childhood.Glucocorticoids are frequently used in the chemoradiotherapy regimen for ALL and can induce the apoptosis of ALL cells through several signaling pathways,but about 10% of ALL children have poor response to glucocorticoids.Studies have revealed that glucocorticoids induce the apoptosis of ALL cells by upregulating the expression of BIM gene,and BIM gene is associated with glucocorticoid resistance in childhood ALL.This article reviews the recent studies on glucocorticoid resistance in childhood ALL,especially the role of BIM and its expression products in this process.