自噬在急性髓细胞白血病中的研究进展

Research progress of autophagy in acute myeioid leukemia

急性髓细胞白血病（AML）是髓系造血干细胞恶性疾病，自噬是溶酶体介导的清除受损细胞器、蛋白质和其他细胞物质的过程。自噬在细胞缺乏营养或其他应激条件下，维持其生存。自噬在AML发病及治疗中发挥重要的作用，可能影响急性髓系白血病细胞的生存、死亡和耐药等。笔者拟讨论自噬在AML中的作用，对其研究进展进行综述。

Acute myeloid leukemia（AML） is a malignant disease of myeloid hematopoietic stem cells. Autophagy is a process of removing damaged organelles, proteins and other cellular substances. Autophagy maintains survival of cell in the absence of nutrients or other stress conditions and plays an important role in the pathogenesis and therapy of AML, which may affect survival, death and drug resistance of AML cells. This paper will discuss the role of autophagy in AML and provide a review for management of acute myeloid leukemia.