康复新液联合医用射线防护剂对头颈部肿瘤放射性皮炎的应用研究

Clinical observation of Kangfuxin fluid combined with medical anti-radiation spray on injury dermatitis induced by radiation in head and neck tumor patients

目的探讨康复新液联合医用射线防护剂治疗头颈部肿瘤放射性皮炎的临床疗效。方法选择90例需行放射治疗的头颈部肿瘤患者随机分成A、B、C 3个组,每组30例。A组患者放射治疗时用康复新液联合医用射线防护剂治疗放射性皮炎;B组患者在放疗时单用医用射线防护剂;C组患者在放疗时单用康复新液。所有患者均行放射治疗,医用射线防护剂与康复新液每日使用3次,使用前与放射治疗结束后拍照片,根据美国肿瘤放射治疗协会皮肤急性放射损伤分级标准评估疗效。结果 A组治疗后有效率高于对照组B组(χ~2=5.76,P<0.05)及C组(χ~2=5.23,P<0.05)。B组与C组患者放射性皮炎疗效比较,差异无统计学意义(χ~2=1.26,P>0.05)。结论康复新液联合医用射线防护剂对防治头颈部肿瘤放射性皮炎有明显疗效,延缓皮肤损伤的发生,加快皮肤损伤的愈合,值得在临床肿瘤放射治疗护理中进一步推广应用。

Objective To study the clinical effects of Kangfuxin fluid combined with medical anti-radiation spray agent on the acute injury dermatitis induced by radiotherapy in head and neck tumor patients. Methods A total of 120 cases who received radio- therapy for head and neck tumor were randomly divided into A,B,C group,30 cases in each group. Group A patients followed trea- ted with the Kangfuxin fluid combined with medical anti-radiation spray agent. Group B patients treated only with medical radiation protective agent during radiotherapy. Group C patients followed with Kangfuxin fluid. Three groups of patients were sprayed with agents on the 3 days undergoing intensity-modulated radiotherapy. Protective effects of injury dermatitis induced by radiotherapy were evaluated and graded according to criteria of Radiation Therapy Oncology Group in pretreatment and post-radiation. Results Patients of three groups all had acute radioactive dermatitis of different degrees. Effective rate of group A was significantly higher than that in the group B（x^2 =5.76,P〈0.05） and group C（x^2 =5.23,P〈0.05）. While,effective rates of group B and C had no statistical differences（x^2 =1.26,P〉0.05）. Conclusion The Kangfuxin fluid combined with medical anti-radiation spray agent has obvious clinical effect on acute radioactive dermatitis. It could delay the happening of skin damage and accelerate the healing of skin damage. It deserves further clinical study in the nurses of tumor radiotherapy.