丹红注射液用于肺源性心脏病急性发作期的疗效观察

Observation on Efficacy of Danhong Injection in Treatment of Pulmonary Heart Disease in Acute Exacerbation

目的:探讨丹红注射液用于肺源性心脏病急性发作期的疗效。方法:选择宜都市第一人民医院2012年1月—2016年1月收治的肺源性心脏病急性发作期患者127例作为研究对象。按随机数字表法分为观察组和对照组和对照组。对照组(63例)患者给予常规抗感染、化痰等治疗,观察组(64例)患者在对照组基础上加用丹红注射液。比较两组患者的总有效率,治疗前后左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)、血液流动学指标变化及并发症发生情况。结果:观察组患者的总有效率为93.85%(60/64),明显高于对照组的66.67%(42/63),差异有统计学意义(P<0.05)。治疗后,观察组患者的LVEDD、LVESD、LVEDV、LVESV明显低于本组治疗前及对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者p H、Pa O2、Pa CO2、呼吸频率、心率均较治疗前明显改善,且观察组患者改善情况明显优于对照组,差异均有统计学意义(P<0.05)。观察组患者的并发症发生率为6.25%(4/64),明显低于对照组的30.16%(19/63),差异有统计学意义(P<0.05);观察组患者住院时间明显短于对照组,差异有统计学意义(P<0.05)。结论:丹红注射液治疗肺源性心脏病急性发作期的疗效较好,可明显改善患者症状、缩短住院时间,安全性较高。

OBJECTIVE ： To probe into the efficacy of Danhong injection in treatment of pulmonaly heart disease in acute exacerbation. METHODS： 127 patients with pulmonary heart disease in acute exacerbation admitted into Yidu the First People＇s Hospital from Jan. 2012 to Jan. 2016 were selected to be randomly divided into observation group and control group. 63 patients in control group were given conventional infection and phlegm, 64 patients in observation group additionally received Danhong injection based on the control group, the total effective rate, changes of LVEDD, LVESD, LVEDV and LVESV levels, hemorheology indicators and incidence of complications of two groups were compared. RESULTS： The total effective rate of observation group was 93.85% （60/64）, significantly higher than that of control group [ 66.67% （42/63） ], with statistically significant difference （ P 〈 0.05 ）. After t^atment, the LVEDD, LVESD, LVEDV and LVESV levels in observation group decreased significantly compared with betbre treatment and control group, with statistically significant diffm^nce （ P 〈 0.05 ）. After treatment, the pH, PaO2, PaCO2, respiratory rate, heart rate of two groups had been improved significantly compared with before treatment, and the observation group was better than that control group, with statistically significant difference （P 〈 0.05 ）. The incidence of adverse drug reactions of observation group was 6.25% （4/64）, significantly lower than that of control group [ 30. 16% （ 19/63 ） ], with statistically significant difference （P 〈 0. 05 ）. The length of hospital in observation group had been shortened significantly compared with control group, with statistically significant difference （ P 〈 0. 05 ）. CONCLUSIONS： acute exacerbation is significant, high safety. The efficacy of Danhong injection in which can significantly improve patients＇ treatment of puhnonaly heart disease in symptoms, shorten the hospital length with