摘要
目的:探讨低剂量氨磺必利治疗精神分裂症阴性症状的疗效及安全性。方法:选取2015年6月—2016年12月赣州市第三人民医院收治的精神分裂症阴性症状患者100例作为研究对象,以随机数字表法分为高剂量组33例、中剂量组33例、低剂量组34例。所有患者给予常规抗精神病药;同时,高剂量组患者给予氨磺必利1日900~1 200 mg,中剂量组患者给予氨磺必利1日400~800 mg,低剂量组患者给予氨磺必利1日50~150 mg。观察三组患者的临床疗效、治疗满意度,比较三组患者阳性与阴性症状量表(positive and negative syndrome scale,PANSS)评分、生活质量评分、不良反应发生情况的差异。结果:低剂量组患者的总有效率、治疗总满意度明显高于高、中剂量组,差异均有统计学意义(P<0.05);低剂量组患者的PANSS评分、生活质量评分明显优于高、中剂量组,差异均有统计学意义(P<0.05);低剂量组患者不良反应发生率明显低于高剂量组,差异有统计学意义(P<0.05)。结论:低剂量氨磺必利治疗精神分裂症阴性症状的疗效显著,不良反应少,安全性高,有利于患者的预后。
OBJECTIVE : To probe into the efficacy and safety of low dose of amisulpride in treatment of negative symptoms of schizophrenia. METHODS: 100 patients with negative symptoms of schizophrenia admitted into Ganzhou the Third People's Hospital from Jun. 2015 to Dec. 2016 were selected and divided into high dose group (33 cases) , medium dose group (33 cases) and low dose group (34 cases) via the random number table. The high dose group was treated with amisulpride 900 rag/d-1 200 rag/d, the medium dose group was treated with amisulpride 400 mg/d- 800 rag/d, and the low dose group was given amisulpride 50 rag/d-150 mg/d. The clinical efficacy and patients' satisfaction of three groups were observed, the positive and negative syndrome scale (PANSS) scores, quality of life scores and incidence of adverse drug reactions of three groups were compared. RESULTS : The total effective rate and patients' satisfaction of the low dose group were significantly higher than those of the high dose group and medium dose group, with statistically significant difference ( P 〈 0.05 ) ; the PANSS scores and quality of life scores of low dose group were significantly better than those of the high dose group and medium dose group, with statistically significant difference (P 〈0. 05) ; the incidence of adverse drug reactions of the low dose group was significantly lower than that of the high dose group, with statistically significant difference (P 〈 0.05 ). CONCLUSIONS : The efficacy of low dose of amisulpride in treatment of negative symptoms of schizophrenia is remarkable, with less adverse drug reactions and higher safety, which is conducive to oatients' prognoses.
出处
《中国医院用药评价与分析》
2017年第6期769-771,共3页
Evaluation and Analysis of Drug-use in Hospitals of China