不同中成药注射剂辅助治疗非小细胞肺癌的对比研究

Comparative Study on Adjuvant Therapy of Different Chinese Patent Medicine Injections in Treatment of Non-small Cell Lung Cancer

目的:探讨不同中成药注射剂辅助治疗非小细胞肺癌的临床疗效。方法:选取2015年6月—2016年11月河南科技大学第一附属医院收治的非小细胞肺癌患者200例作为研究对象,以计算机随机分配为A、B、C、D组,每组50例。A组患者采用常规治疗,包括化疗、放疗、支持治疗等;B、C、D组患者在A组的基础上分别加用艾迪注射液、康莱特注射液、参芪扶正注射液。观察四组患者的临床疗效及不良反应发生情况。结果:四组患者总有效率的差异无统计学意义(P>0.05);B、C、D组患者疾病控制率的差异无统计学意义(P>0.05),但均明显高于A组,差异有统计学意义(P<0.05)。B、C、D组患者恶心呕吐、腹泻的发生率明显低于A组;B、D组患者白细胞减少症发生率明显低于A组;C、D组患者肾损害发生率明显低于A组,差异均有统计学意义(P<0.05);四组患者药物热发生率的差异无统计学意义(P>0.05)。结论:艾迪注射液、康莱特注射液、参芪扶正注射液均可有效控制非小细胞肺癌的进展,并能不同程度地减轻放化疗的毒副作用,改善患者生活质量。

OBJECTIVE ：To probe into the clinical efficacy of adjuvant therapy of different Chinese patent medicine injections in treatment of non-small cell lung cancer （NSCLC）. METHODS： 200 patients with NSCLC admitted into the First Affiliated Hospital of Henan University of Science and Technology from Jun. 2015 to Nov. 2016 were selected and randomly divided into group A, B, C and D by computer, with 50 cases each group. A group was givenconventional therapy, included chemotherapy, radiotherapy, supporting therapy, etc. Group B, C and D were respectively treated with addle injection, kanglaite injection and shenqifuzheng injection based on group A. The efficacy and incidence of adverse drug reactions of four groups were observed. RESULTS： There was no statistical significance in total effective rate among four groups （P 〉 0. 05） ; the disease control rates of group B, C and D were significantly higher than that of group A, with statistically significant difference （P 〈 0. 05 ）, while with no statistically significant difference among group B, C and D （P 〉 0. 05 ）. The incidence of nausea, vomiting anddian＇hea of group B, C and D were significantly lower than those of group A; the incidence of leucopenia of group B and D were significantly lower than that of group A; the incidence of renal function damage of group C and D were significantly lower than that of group A, with statistically significant difference （P 〈 0. 05 ）. There was no statistical significance in incidence of drug fever among four groups （P 〉 0. 05 ）. CONCLUSIONS： Addle injection, kanglaite injection and shenqifuzheng injection can effectively control the progress of NSCLC, relieve the toxic and side effect of chemotherapy and improve patients＇ quality of life.