ABO血型不合干细胞移植患者红细胞“配合型输血”的临床研究

A Clinical Investigation of Matched Blood Transfusion in the Patients with Stem Cell Transplants of ABO Incompatibility

目的研究ABO血型不合干细胞移植患者嵌合体期间红细胞"配合型输血"的特点。方法调取ABO血型不合患者25例,分析嵌合体血型特征,包括嵌合体期间患者红细胞表面抗原与血清抗体分布;分析"配合型输血",即嵌合体的红细胞输注方案;评价配血型输血疗效,分析输血反应。结果 25例干细胞移植ABO血型不合患者,根据嵌合体期间患者红细胞表面抗原与血清抗体分布选择红细胞"配合型输血",有效输血76.38%,嵌合体各组红细胞输注前后Hb差异均有统计学意义,不良反应3次,均为非溶血性发热反应。结论 ABO血型不合干细胞移植患者,嵌合体期间选择红细胞"配合型输血",可有效提高患者Hb水平,保证输血安全。

Objective To study the characteristics of the ＂matched blood transfusion＂ in the patients with stem cell transplants of ABO incompatibility.Methods Twenty five casesof ABO blood group incompatibility were detected for their blood group chimericcharacteristics,including the surface antigen of red blood cells （RBCs） and serum antibody alteration. Scheme of transfusion of chimericRBCs andthe effect and adverse reactions following transfusion were evaluated.Results Twenty five patients with stem cell transplants and ABO incompatibility received matched blood transfusion based on the surface antigen of RBCs and serum antibody alteration in chimera,and the transfusion efficacyof 76.38% was obtained. A significantly increased HB levelinpre- and post- transfusions was noted although 3 times of adverse reactions such as non-hemolytic febrile occurred. Conclusion The matched red blood cell transfusion in the patients with chimeric stem cell transplants and ABO incompatibility may help elevate the HB level and ensure the transfusion safety.