TGAb、TMAb和TPOAb诊断在桥本甲状腺炎诊断中的价值

Value of TGAb, TMAb and TPOAb in diagnosis of hashimoto thyroiditis

目的分析甲状腺球蛋白抗体(TGAb)、甲状腺微粒体抗体(TMAb)和抗甲状腺过氧化物酶抗体(TPOAb)在桥本甲状腺炎诊断中的价值。方法选取疑似桥本甲状腺炎患者57例,以临床或病理诊断为金标准,确诊为桥本甲状腺炎的有54例。检测所有患者的TGAb、TMAb和TPOAb水平,计算TGAb、TMAb和TPOAb水平诊断桥本甲状腺炎的灵敏度、特异度和符合度。结果桥本甲状腺炎患者的TGAb、TMAb和TPOAb水平均明显高于正常参考值(P<0.05);3项指标诊断的灵敏度和符合率之间有显著差异(P<0.05),其中以TPOAb的灵敏度和符合率最高,而TGAb的特异度明显高于TPOAb和TMAb(P<0.05)。结论检测TPOAb和TGAb水平对桥本甲状腺炎的诊断具有较高的诊断价值,但应根据具体情况选择合适的指标辅助诊断,对于疾病筛查宜选择检测灵敏度较高的TPOAb,临床诊断上则宜选择检测特异度较高的TGAb。

Objective To analyze the value of thyroglobulin antibodies （TGAb）, thyroid microsomal antibody （TMAb） and anti-thyroid peroxidase antibody （TPOAb） in the diagnosis of hashimoto thyroiditis. Me出ods A total of 57 patients with suspected hashimoto thyroiditis were selected and 54 patients were diagnosed with hashimoto thyroiditis with clinical or pathological diagnosis as the gold standard. The TGAb, TMAb and TPOAb levels of all patients were detected to calculate the sensitivity, specificity and compliance of. TGAb, TMAb and TPOAb levels in the diagnosis of. hashimoto thyroiditis. Results The TGAb, TMAb and TPOAb levels of patients with hashimoto thyroiditis were significantly higher than the normal reference value （P 〈 0.05）; there were significant differences in the diagnosis sensitivity and coincidence rate among the three indexes （P 〈 0.05）, and the sensitivity and coincidence rate of TPOAb were the highest, but the specificity of TGAb was significantly higher than that of TPOAb and TMAb （P 〈 0.05）. Conclusion The detection of TPOAb and TGAb levels has high value in the diagnosis of hashimoto thyroiditis, but appropriate index should be selected according to specific circumstances to assist the diagnosis. For example, TPOAb with higher sensitivity is preferred for disease screening, while TGAb with higher specificity is preferred for clinical diagnosis.