人巨细胞病毒抗体筛查预防输血性人巨细胞病毒感染的Meta分析

A Meta-analysis on effect of antibody blood screening in preventing transmission of cytomegalovirus by transfusion

目的明确输注人巨细胞病毒(CMV)血液抗体筛查阴性血在减少免疫低下人群输血性CMV感染的作用,为CMV抗体血液筛查的实施提供依据。方法计算机检索PubMed、MEDLINE、Ovid、ProQuest、EBSCO、Cochrane Library、EMbase、CNKI、VIP、CBM和WanFang数据库,检索比较输入CMV血液抗体筛查阴性血与输入未经筛查且为非去白细胞处理血对输血性CMV感染率差异的文献,同时辅以手检纳入文献的参考文献。按照纳入排除标准进行筛选、资料提取和质量评价后,使用Rev Man5.1软件进行Meta分析。结果共纳入7项研究,430例患者。Meta分析结果显示输入经CMV血液抗体筛查阴性血与输入未经筛查且为非去白细胞处理血后,受血者的输血性CMV感染率差异具有统计学意义(OR=0.07,95%CI:0.03~0.18,P<0.01)。结论进行CMV抗体血液筛查能有效减少免疫低下受血者输血性CMV感染率,特别对器官移植和新生儿输血患者作用明显。

Objective To determine the effect of using cytomegalovirus-seronegative blood components in preventing transfusion-acquired cytomegalovirus infection,which laid foundation for the application of blood antibody screening of cytomegalovirus.Methods The documents of studies about the comparison in transfusion-acquired cytomegalovirus ratio between using cytomegalovirus-seronegative blood components with using cytomegalovirus-unscreened/non-WBC-reduced blood were retrieved from the databases of PubMed,MEDLINE,Ovid,ProQuest,EBSCO,Cochrane Library,EMbase,CNKI,VIP,CBM and WanFang Library,and the reference in studies were retrieved by hands at the same time.The documents were screened,extracted and evaluated according to inclusion and exclusion criteria,and then given a Meta-analysis by using Rev Man 5.1software.Results There were totally 7controlled studies（430patients）included.The results of Meta-analysis showed that compared with using cytomegalovirus-unscreened/non-WBC-reduced blood,the effect of using cytomegalovirus-seronegative blood components in preventing transfusion-acquired cytomegalovirus infection had a statistical difference（OR=0.07,95%CI：0.03-0.18,P〈0.01）.Conclusion Application of blood antibody screening of cytomegalovirus is effective in preventing transfusion-acquired cytomegalovirus infection,especially organ transplantation and neonate patients.