跨膜丝氨酸蛋白酶4蛋白在直肠癌中的表达及临床意义

The expression and clinical significance of TMPRSS4 protein in rectal carcinoma

目的:探讨TMPRSS4蛋白在直肠癌中的表达及临床意义。方法:应用免疫组织化学SP法检测TMPRSS4蛋白在62例患者的直肠癌组织中的表达,取癌旁组织62例作为对照组。结果:直肠癌中TMPRSS4蛋白的表达明显高于癌旁组织(P<0.01)。TMPRSS4蛋白在穿透浆膜层、TNM(III+IV)期、有淋巴结转移组中的表达显著高于未穿透浆膜层(P<0.05)、TNM(I+II)期(P<0.01)、无淋巴结转移组(P<0.01),且与年龄、性别、肿瘤部位、肿瘤大小和分化程度无关(P>0.05);TMPRSS4蛋白阳性表达组的五年生存期明显短于阴性表达组(P<0.05)。结论:TMPRSS4蛋白在直肠癌中高表达,联合检测直肠癌的临床病理参数和TMPRSS4蛋白的表达有助于判断患者的预后。

ObjectiveTo investigate the expression and clinical significance of TMPRSS4 protein in rectal carci-noma. Methods ： The expressions of TMPRSS4 protein in 62 patients with rectal carcinoma were detected by immuno- histochemistry（ SP method） . 62 adjacent mucosa served as control group. Results ：The expression of TMPRSS4 protein in rectal carcinoma was significantly higher than that in adjacent mucosa（P 〈0. 01） . the TMPRSS4 protein expression level in outside the serosa invasion, lymph node metastasis and TNM stages （Ⅲ ＋ Ⅳ） group were significantly higher than that in within the serosa （ P 〈 0. 05 ） , lymph node metastasis - free group （P 〈 0 .0 1 ） and TNM stage （ Ⅰ ＋ Ⅱ） group（ P 〈 0. 01 ） . but had no relations with age, sex, tumor size and tumor differentiation（ P 〉 0. 05 ） . The five - year survival rate of the patients with positive expression of TMPRSS4 protein was significant lower than those with negative expression of TMPRSS4 protein（P 〈 0. 05 ）. Conclusion ： TMPRSS4 protein was overexpressed in rectal carcinoma. Combined determination of TMPRSS4 protein expression and clinicopathology indicators of rectal carcinoma were help-ful in prediction of patients prognosis.