子宫内膜癌组织中DcR3的表达及临床意义

Expression and clinical significance of DcR3 in human endometrial carcinoma tissues

目的:检测DcR3在正常增生期子宫内膜、子宫内膜非典型增生和子宫内膜癌组织中的表达,探讨它们在子宫内膜癌发生、发展中的作用。方法:用免疫组织化学法检测DcR3在不同子宫内膜组织中的表达情况。结果:DcR3在子宫内膜癌组织中的表达水平均高于子宫内膜非典型增生和增生期子宫内膜组织(P<0.01)。DcR3的表达与子宫内膜癌的临床分期和有无淋巴结转移有关(P<0.05),但与不同病理类型、组织学分级无关(P>0.05)。结论:DcR3在子宫内膜癌的发生、发展过程中可能起着重要的作用。

ObjectiveTo detect the expressions of DcR3 protein in the tissue of proliferative phase endometrium、 endometrial atypical hyperplasia and endometrial carcinoma, and to explore its clinical significance in the development of endometrial carcinoma. Methods ： Immunohistochemistry was performed to detect the expressions of DcR3 in differ-ent endometrial tissue. Results： The expression level of DcR3 protein in endometrial carcinoma was significantly high-er than that in proliferative phase endometrium and endometrial atypical hyperplasia （ P 〈 0. 01 ） . The expression of DcR3 was related to the clinical stages and lymph node metastasis of endometrial carcinoma（P 〈0. 05） ,but not cor-related with pathological type and pathological grade of endometrial carcinoma（ P 〉 0. 05 ） . Conclusion ： DcR3 maybe plays a important role in the tumorigenesis and progress of endometrial carcinoma .