中性粒细胞淋巴细胞比率对于预测卵巢癌患者预后的Meta分析

Prognostic significance ofneutrophil-to-lymphocyte ratioin ovarian cancer:A systematic review and metaanalysis of observational studies

目的分析中性粒细胞淋巴细胞比率对预测卵巢癌患者预后的意义。方法计算机检索Pub Med、Web of Science、Embase三大数据库,查找相关研究,检索时限从建库至2016年5月。对纳入的文章进行质量评价,计算危险比(HR)和优势比(OR)及95%置信区间(CI),采用Stata12.0软件进行Meta分析。结果治疗前高NLR水平患者总生存期(OS)(HR 1.69)和无进展生存期(PFS)(HR 1.63)较短,差异均有统计学意义。此外,卵巢癌患者高NLR与其FIGO分期晚期(OR 2.32)、CA-125升高(OR 3.33)、腹水(OR 3.54)以及化疗敏感性降低(OR 0.53)显著相关。结论治疗前NLR升高可作为卵巢癌患者预后不良的提示。

Objective To obtain a more accurate assessment of prognostic significance of NLR in ovarian cancer.Methods A systematic literature search was conducted using the electronic databases Pub Med,Web of Science,and Embase up to May 2016.Hazard ratio(HR)and odds ratio(OR)with 95%confidence interval(95%CI)were calculated.Statistical analysis was performed using Stata 12.0.Results 12 studies,consisting of 3,854 patients,were selected in this meta-analysis.High NLR level was significantly associated with poorer overall survival(OS)(HR:1.69)and shorter progression free survival(PFS)(HR 1.63).Additionally,increased NLR was significantly correlated with advanced FIGO stage(OR 2.32),higher level of CA-125(OR 3.33),more extensive ascites(OR 3.54)as well as less chemotheraputic response(OR 0.53).Conclusions Elevated pretreatment NLR can serve as a predicative factor of poor prognosis for ovarian cancer.