CD133和p53在结直肠癌中的表达及临床意义

Expressions of CD133 and p53 in colorectal carcinoma and the clinical relvance

目的探讨结直肠癌组织中CD133和p53蛋白的表达及临床病理意义。方法采用免疫组化方法检测74例结直肠癌组织中CD133和p53蛋白的表达情况,并分析其与结直肠癌临床病理参数及预后的关系。结果 CD133和p53蛋白的表达阳性率分别为33.8%和55.4%,二者表达阳性率与结直肠癌患者年龄、性别、肿瘤发生部位及组织学类型均无关(P>0.05),而与分化程度、TNM分期及是否发生远处转移有关,差异均有统计学意义(P<0.05)。Spearman相关性分析结果显示CD133和p53的表达并无相关性。结论 CD133和p53的表达与结直肠癌分化程度及TNM分期密切相关,可作为评价结直肠癌恶性生物学行为、诊疗及预后的重要生物标志物。

Objective To investigate the expressions of CD133 and p53 in colorectal cancer and their clinical significances.Methods The expressions of CD133 and p53 in 74 colorectal cancer patients were detected by the immunohistochemistry method.The relationships of CD133 and p53 with the clinicopathological parameters and prognosis were analyzed.Results The positive expression rates of CD133 and p53 in colorectal cancer tissues were 33.8% and 55.4%,respectively.The expression levels of CD133 and p53 were not related to age,sex,tumor location and histological type,and but were significantly related to the histological differentiation,TNM stage and distant metastasis（P〈0.05,respectively）.The Spearman correlation analysis showed that there was no correlation between the levels of CD133 and p53.ConclusionsThe high expressions of CD133 and p53 in colorectal cancer tissues were closely related to the histological differentiation and TNM stage.CD133 and p53 could be used as important biomarkers for the evaluation of malignant biological behavior,and the diagnosis and prognosis of colorectal cancer