益生菌辅助糖皮质激素对湿疹治疗的疗效及机制分析

Study on the efficacy and mechanism of probiotic assisted glucocorticoid on the treatment of the patients with eczema

目的 研究益生菌辅助糖皮质激素对湿疹治疗的疗效及机制。方法 将于2015年2月-2017年3月就诊的湿疹患者92例根据治疗方式分为常规治疗组和联合治疗组,每组46例。常规治疗组采用糖皮质激素制剂治疗;联合治疗组采用益生菌辅助糖皮质激素制剂治疗。就2组患者治疗前后血清炎症因子水平和湿疹治疗效果、不良反应发生率进行比较。结果 联合治疗组湿疹治疗效果明显高于常规治疗组（P〈0.05）。2组患者无严重不良反应发生。治疗前2组的血清炎症因子水平差异无统计学意义。治疗后联合治疗组患者血清炎症因子水平均明显优于常规治疗组（P〈0.05）。结论 益生菌辅助糖皮质激素制剂对湿疹治疗的疗效确切,可更好降低机体炎症水平,改善病情,无明显不良反应,安全有效。

Objective To study the efficacy and mechanism of probiotic assisted glucocorticoid on the treatment of the patients with eczema. Methods 92 cases with eczema from February 2015 to March 2017 were divided into two groups according to the treatment methods, the conventional group and the combined group, 46 cases in each group. The conventional group were given glucocorticoid, and the combined treatment group were received probiotics combined with glucocorticoid. The levels of serum inflammatory factors, the treatment effects of eczema and the incidence of adverse reactions were compared between the two groups before and after treatment. Results The treatment effect of eczema in combined group was higher than that in routine group （P〈0.05）. No severe adverse reactions occurred in the two groups. There was no significant difference in serum inflammatory factors between the two groups before treatment. The level of serum inflammatory factors in combined group was significantly better than that in tconventional group （P〈0.05）. Conclusion Probiotic assisted glucocorticoid is effective in the treatment of eczema. It can lower the level of inflammation and improve the condition of the body. It has no obvious adverse reaction which has the characteristics of safety and effectiveness.