金刚藤胶囊在盆腔炎患者中的疗效观察及对子宫组织炎症因子及内膜细胞凋亡的影响研究

Effect of Jingangteng capsule on pelvic inflammatory disease and its influence on uterine inflammatory factors and neointima cell apoptosis

目的 观察金刚藤胶囊对盆腔炎患者子宫组织炎症及内膜细胞凋亡的影响。方法 选取2015年5月-2016年8月医院收治盆腔炎患者60例,随机分为2组。对照组采用康妇消炎栓治疗,观察组采用金刚藤胶囊治疗,采用酶联免疫吸附试验检测2组治疗前、后炎症因子水平,采用免疫组化试验检测子宫组织FasL、Caspase-3、Caspase-8水平,比较2组临床疗效及对子宫组织炎症及内膜细胞凋亡的影响。结果 观察组治疗后TNF-a、IL-1β、IL-8水平低于对照组（P〈0.05）;观察组治疗后IL-10水平高于对照组（P〈0.05）;观察组治疗后FasL、Caspase-3、Caspase-8水平高于对照组（P〈0.05）。结论 盆腔炎患者采用金刚藤胶囊治疗效果理想,值得推广应用。

Objective To observe the effect of Jingang Capsule on the inflammation and apoptosis of endometrial tissue in patients with pelvic inflammatory disease. Methods From May 2015 to August 2016 hospital admitted 60 cases of pelvic inflammatory disease, they were randomly divided into 2 groups. The control group using kangfuxiaoyan suppository treatment, observation group with Jingangteng capsule, using enzyme-linked immunosorbent assay in 2 groups before and after treatment, the levels of inflammatory factors, using immunohistochemical detection of uterine tissue FasL, Caspase-3, Caspase-8 level test, comparison of 2 groups of clinical curative effect and effect on uterine endometrial tissue inflammation and apoptosis the. Results The observation group after treatment TNF-a, IL-1 beta, IL-8 levels lower than the control group （P〈0.05）;the observation group after treatment, the level of IL-10, higher than that of the control group （P〈0.05）; the observation group after treatment FasL, Caspase-3, Caspase-8 levels higher than the control group （P〈0.05）. Conclusion It is ideal for the treatment of patients with pelvic inflammatory disease to be treated with Jin Teng capsule. It is worthy of popularization and application.