羟苯磺酸钙对维持性血液透析患者血清Hs-CRP和TNF-α等炎症指标的影响

Study on the effects of calcium dobesilate on serum Hs-CRP and TNF-α and other micro-inflammatory in patients with maintenance hemodialysis

目的 研究羟苯磺酸钙对维持性血液透析患者血清Hs-CRP和TNF-α等微炎症指标的影响。方法 选取2015年4月-2016年12月内蒙古医科大学附属医院收治的74例慢性肾衰竭并行维持性血液透析患者进行研究分析,所有患者均符合中华中医药学会制定的《慢性肾衰竭诊疗指南》中的诊断标准,将其随机分为对照组和观察组,分别为39例、35例患者。给予所有患者阿托伐他汀治疗,观察组患者同时予以羟苯磺酸钙治疗。结束治疗后对2组患者的炎症指标超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）,以及营养指标血浆白蛋白（ALB）,前白蛋白（PA）水平,进行详细的比较分析。结果 治疗后,两组患者hs-CRP、TNF-α水平均低于治疗前,差异有统计学意义（P〈0.05）;观察组hs-CRP、TNF-α水平显著低于对照组,差异具有统计学差异（P〈0.05）;观察组患者治疗后营养指标ALB、PA明显高于对照组,差异有统计学意义（P〈0.05）。结论 对于维持性血液透析患者进行治疗时,采用常规阿托伐他汀治疗基础上加用羟苯磺酸钙可以有效的改善患者炎症状况及营养状态,安全性较高,具有临床进一步推广和应用的意义。

Objective To study the effect of calcium dobesilate on serum Hs-CRP and TNF-α and other micro-inflammatory in patients with maintenance hemodialysis. Methods 74 patients with chronic renal failure undergoing maintenance hemodialysis from April 2015 to December 2016, were randomly divided into the control group（n=39） and the observation group（n=35）. All patients are in line with the diagnostic criteria of the guidelines for the diagnosis and treatment of chronic renal failure, established by the Chinese Academy of traditional Chinese Medicine. All patients in the two groups were given atorvastatin, at this basis, the observation group was given calcium dobesilate. After treatment, hypersensitive inflammatory markers, such as C-reactive protein （hs-CRP）, tumor necrosis factor -α （TNF-α）, as well as nutrient index plasma albumin （ALB） and the pre-albumin （PA） level in the two groups were compared. Results The hs-CRP, TNF-α in the observation groupwere lower than that in the control group, the differences was statistically significant （P〈0.05）. The ALB, PA in the observation group was significantly higher than that in the control group, the differences was statistically significant （P〈0.05）. Conclusion Atorvastatin combined with calcium dobesilate was used in the patients with maintenance hemodialysis which can improve thenutritional status and inflammatory conditions, it is safety and is worth popularizing,.