心理干预联合氯吡格雷、阿司匹林肠溶片对冠心病心绞痛疗效观察

Effect of psychological intervention combined with clopidogrel and Aspirin Enteric-coated Tablets on angina pectoris of coronary heart disease

目的 针对联合治疗方案（心理干预＋氯吡格雷＋阿司匹林肠溶片）治疗冠心病心绞痛的效果进行研究。方法 选取2016年1月-2017年4月,到杭州市中医院进行治疗的冠心病心绞痛患者88例。采取随机的方式,将患者分为治疗组和对照组,每组44例。对照组患者采用阿司匹林肠溶片治疗,治疗组患者采用联合治疗方案（心理干预＋氯吡格雷＋阿司匹林肠溶片）。观察并对比2组患者的治疗效果、心绞痛发作情况、不良反应发生情况。结果 对比2组患者的治疗效果,治疗组总有效率为97.73%,对照组总有效率为79.55%,差异有统计学意义（P〈0.05）;对比2组患者的心绞痛发作情况,治疗组患者的发作时间（4.32±1.18）更短,发作间隔时间（5.03±1.34）更长,发作次数（1.67±0.49）更少,差异有统计学意义（P〈0.05）;对比2组患者的不良反应发生情况,治疗组的不良反应发生率为4.55%,低于对照组不良反应发生率18.18%,差异有统计学意义（P〈0.05）。结论 心理干预联合氯吡格雷、阿司匹林肠溶片的治疗方案,在冠心病心绞痛患者的临床治疗上,显示出良好的治疗效果,具有较高的应用价值。

Objective To study the effects of combination therapy （psychological intervention＋clopidogrel＋aspirin） for coronary heart disease. Methods 88 cases were selected from January 2016 to April 2017 in patients with coronary heart disease in our hospital. In a randomized approach, patients were divided into treatment groups and control groups, with 44 cases per patient. Patients in the control group were treated with aspirin, and the treatment group was treated with a combination therapy （psychological intervention＋clopidogrel＋aspirin）. The treatment effect, angina and adverse reaction were observed and compared. Results Comparing the therapeutic effect of two groups of patients, the treatment group total effective rate was 97.73%, control group total effective rate was 79.55%, significant difference was statistically significant （P〈0.05）; Compared two groups of patients with angina, the treatment group patients with onset time （4.32±1.18） shorter, longer time interval （5.03 ±1.34）, less number of attacks （1.67±0.49）, with statistical significance （P〈0.05）; Compared to the adverse reactions in the two groups, the incidence of adverse reactions in the treatment group was 4.55%, compared with 18.18% in the control group. Statistical significance （P〈0.05）. Conclusion Psychological intervention in combination with clopidogrel and aspirin enteric-coated metformin hydrochloride in the treatment, in the clinical treatment of patients with coronary heart disease angina pectoris, shows good therapeutic effect, has higher application value.