利伐沙班与低分子肝素防治膝关节置换术后深静脉血栓的疗效对比

Efficacy of Shaaban and low molecular weight heparin in prevention and treatment of deep venous thrombosis after knee replacement

目的 比较利伐沙班与低分子肝素防治膝关节置换术后下肢深静脉血栓的治疗效果。方法 选取2011年1月-2013年1月间在本院行膝关节置换术的120例患者作为研究对象,分观察组和对照组,观察组患者采用口服利伐沙班进行抗凝治疗,对照组采用皮下注射低分子肝素进行治疗,比较2组患者术后深静脉血栓发生率、治疗14 d后患者凝血指标情况和药物不良反应情况。结果 观察组患者深静脉血栓发生率为1.67%,明显低于对照组的13.34%,差异有统计学意义（P〈0.05）;2组患者治疗14 d后PLT、APTT和PT水平差异无统计学意义;观察组患者药物不良反应发生率为5.00%,明显低于对照组的13.34%,差异有统计学意义（P〈0.05）。结论 与低分子肝素相比,应用利伐沙班的膝关节置换术后患者深静脉血栓形成的发生率更低,不良反应更少,疗效更为显著。

Objective To compare the efficacy of Shaaban and low molecular weight heparin in the prevention and treatment of deep venous thrombosis of lower extremity after knee replacement. Methods January 2011 to 2013 year in January in our hospital 120 cases of knee joint replacement patients as the research object, divided into observation group and control group, the observation group were treated by oral anticoagulant treatment of Lee Shaaban, the control group by subcutaneous injection of low molecular weight heparin treatment than patients were compared between the two groups after deep vein thrombosis the incidence of 14d after treatment, adverse reactions and blood coagulation indexes in patients with drug. Results The observation group of patients with deep vein thrombosis rate was 1.67%, significantly lower than the control group 13.34%, the difference was statistically significant （P〈0.05）; no statistical significance in two groups of patients after the treatment of 14d PLT, APTT and PT level difference; the observation group of patients with drug adverse reaction incidence rate was 5%. The 13.34% was significantly lower than the control group, the difference was statistically significant （P〈0.05）. Conclusion Compared with low molecular weight heparin, the incidence of deep vein thrombosis is lower, the adverse reactions are less, and the curative effect is more obvious after applying Shaaban＆#39;s knee replacement.