心理干预联合马来酸依那普利片对维持性血液透析患者血清微炎症指标和营养指标的影响

Effects of enalapril maleate tablets on serum micro inflammatory indexes and nutritionalindexes in maintenance hemodialysis patients

目的 研究分析心理干预联合马来酸依那普利片对维持性血液透析患者血清微炎症指标和营养指标的影响。方法 选取丽水市中心医院2015年4月-2016年10月收治的90例慢性肾衰竭并行维持性血液透析患者为研究对象,随机分为对照组和观察组,每组45例。对照组采用阿托伐他汀进行治疗,观察组采用阿托伐他汀联合马来酸依那普利片进行治疗。治疗后对2组患者的炎症标志物超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）、白介素-8（IL-8）、白介素-6（IL-6）以及营养指标血浆白蛋白（ALB）、前白蛋白（PA）水平进行对比分析。结果观察组治疗后hs-CRP、TNF-α水平均低于对照组,差异有统计学意义（P〈0.05）;观察组IL-6、IL-8水平明显低于对照组,差异有统计学意义（P〈0.05）。观察组患者治疗后营养指标ALB、PA明显高于对照组,差异有统计学意义（P〈0.05）。结论 对于维持性血液透析患者进行治疗时,采用常规阿托伐他汀治疗基础上加用马来酸依那普利片临床效果较好,安全性较高,具有临床进一步推广和应用的意义。

Objective To investigate the influence of Enalapril Maleate Tablets on serum micro inflammatory indexes and nutritional indexes in maintenance hemodialysis patients. Methods A total of 90 patients with chronic renal failure treated by maintenance hemodialysis in our hospital from April 2015 to October 2016 were randomly divided into control group and experimental group, with 45casesin each group. The control group was treated with atorvastatin,andthe observation group was treated with atorvastatin combined with enalaprilmaleate tablets. After treatment,the levels of the inflammatory markers of high sensitive C reactive protein （HS-CRP）, tumor necrosis factor alpha （TNF-alpha）, interleukin-8 （IL-8）, interleukin 6 （IL-6） and the nutritional index of plasma albumin（ALB）, prealbumin（PA） in two groups were analyzed. Results After treatment, the levels ofHS-CRP, TNF-alpha in the observation group were lower than those in control group, the difference was statistically significant （P〈0.05）; The levels of IL-6, IL-8 in the observation group were significantly lower than the control group, the difference was statistically significant （P〈0.05）. The indexes of ALB and PA in the observation group after treatment were higher than those in the control group, the difference was statistically significant （P〈0.05）. Conclusion For the patients with maintenance hemodialysis treatment, the clinical effect of using conventional atorvastatin treatment combined with Enalapril Maleate Tablets is good, high safety, with further clinical promotion and application significance.