氟比洛芬给药时机对腹腔镜下急性化脓性阑尾炎切除术患者术后炎性因子的影响

Effect of flurbiprofen administration on postoperative inflammatory factors in patients undergoing laparoscopic acute suppurative appendicitis

目的 探讨氟比洛芬给药时机对腹腔镜下急性化脓性阑尾炎切除术患者术后炎性因子的影响。方法 选取2015年1月-2017年3月于解放军第一一七医院行急性化脓性阑尾炎切除术的患者60例,依不同给药时机分为2组。对照组于手术完成时给药氟比洛芬,观察组于手术麻醉诱导前给药氟比洛芬;对2组患者各项手术指标、手术前后炎性因子水平变化情况进行对比分析。结果 2组患者各项手术指标情况比较,差异无统计学意义;观察组患者术后24小时炎性因子水平情况优于对照组,差异有统计学意义（P〈0.05）。结论 选择于手术麻醉诱导前为患者给药氟比洛芬的效果显著,患者术后炎性因子控制效果佳,于该时机给药并不会影响到患者术后镇痛。

Objective To investigate the effect of flurbiprofen administration time on inflammatory factors in patients with acute suppurative appendicitis after laparoscopic resection. Methods 60 patients with acute suppurative appendicitis resection treated in our hospital from January 2015 to March 2017 were divided into two groups according to the different administration time. The control group received flurbiprofen at the time of operation, and the observation group received flurbiprofen before operation induction; The changes of the indexes of operation and inflammatory factors before and after the operation were compared between the two groups. Results There were no significant differences between the two groups in each operation index; The level of inflammatory factors in the observation group was better than that in the control group 24 hours after the operation, the difference was statistically significant （P〈0.05）. Conclusion The effect of flurbiprofen is significant before the induction of anesthesia, and the control effect of inflammatory factors is good after the operation, and the time will not affect the postoperative analgesia.