TCT、人乳头瘤病毒DNA检查联合阴道镜检查在宫颈癌早期筛查中的价值研究

Study of value of TCT, human papillomavirus DNA and colposcopy in the early screening of cervical cancer

目的 研究TCT、人乳头瘤病毒DNA检查联合阴道镜检查在宫颈癌早期筛查中的价值。方法 对浙江省杭州市江干区凯旋街道卫生服务中心2011年1月-2017年1月收治的80例宫颈病变患者的临床资料进行回顾性分析。结果 80例患者中,TCT检查ASCUS8例,LSIL6例,HSIL4例,SCC2例,宫颈病变检出率为25.0%（20/80）;正常及炎症60例,占总数的75.0%（60/80）。HPV-DNA检查阳性28例,阴性52例,阳性率为35.0%（28/80）;TCT（＋）HPV（＋）的检出率显著高于TCT（＋）HPV（-）、TCT（-）HPV（＋）、TCT（-）HPV（-）（P〈0.05）,对SCC达到了100%的检出率;TCT检查、HPV-DNA检查联合阴道镜检查对CINⅠ、CINⅡ、CINⅢ的检出率均显著高于TCT＋HPV-DNA检查（P〈0.05）,但二者对SCC的检出率之间的差异无统计学意义。结论 TCT、人乳头瘤病毒DNA检查联合阴道镜检查在宫颈癌早期筛查中具有较高的价值,值得在推广使用。

Objective To study the value of TCT, human papillomavirus DNA combined with colposcopy in the early screening of cervical cancer. Methods The clinical data of 80 cases of patients with cervical lesions in our hospital from January 2011 to January 2017 were retrospectively analyzed. Results Among the 80 cases of patients, ASCUS was detected by TCT 8 cases, LSIL6 cases, HSIL4 cases, SCC2 cases, the detection rate of cervical lesions was 25.0% （20/80）; Normal and inflammatory 60 cases, accounting for 75.0% （60/80） of the total. HPV-DNA positive 28 cases, negative 52 cases, the positive rate was 35.0% （28/80）; The detection rate of TCT （＋） HPV （＋） was significantly higher than TCT （＋） HPV （-）, TCT （-） HPV （＋）, TCT （-） HPV （-） （P〈0.05）, the detection rate of SCC reached 100.0%; The detection rate of CIN I, CIN II, CIN III of TCT examination, HPV-DNA examination combined with colposcopy were significantly higher than TCT＋HPV-DNA examination （P〈0.05）, but the difference of detection rates of SCC between the two was not significant. Conclusion The value of TCT, human papillomavirus DNA and colposcopy in the early screening of cervical cancer is higher, so is worthy of promotion and use in the clinical.