术中、术后使用神经节苷脂对脑外伤患者认知功能障碍的影响效果分析

Effect of cognitive dysfunction of gangliosides on in the treatment of the patients with traumatic brain injury intraoperative and postoperative

目的 研究分析术中、术后使用神经节苷脂对脑外伤患者认知功能障碍的影响效果。方法 选取义乌市中心医院2015年2月-2016年8月收治的100例脑外伤手术后出现认知功能障碍的患者,随机分为对照组和试验组2组,每组50例。对照组患者给予相关的常规治疗,包括服药脑复康以及脱水和降低颅内压治疗。在对照组治疗的基础上,试验组患者给予神经节苷脂治疗。比较分析试验组与对照组患者的相关临床指标。结果 试验组痊愈率为90.0%,对照组痊愈率为54.0%,试验组患者痊愈率显著高于对照组患者,差异具有统计学意义（P〈0.05）。治疗前,试验组与对照组患者的MMSE评分的差异无统计学意义;治疗后,试验组患者的MMSE评分为（28.34±4.12）分,对照组患者的MMSE评分为（22.19±5.49）分,试验组患者MMSE评分显著高于对照组,差异具有统计学意义（P〈0.05）。结论 术中、术后使用神经节苷脂治疗脑外伤患者认知功能障碍治疗效果较好,痊愈率较高,具有临床进一步推广和应用的意义。

Objective To study the effect of cognitive dysfunction of gangliosides on in the treatment of the patients with traumatic brain injury intraoperative and postoperative. Methods From February 2015 to August 2016, 100 patients with cognitive dysfunction after operation were randomly divided into two groups, the control group and the experimental group, 50 cases in each group. The control group were received routine treatment, including medication, brain rehabilitation, and dehydration and intracranial pressure reduction. At this basis, the experimental group were treated with gangliosides. The clinical indexes in the experimental group and the control group were compared and analyzed. Results The cure rate was 90% in the experimental group, and 54% in the control group. The difference in the two groups has statistically significant （P〈0.05）. Before treatment, there was no significant difference of the MMSE in the two groups. After treatment, the MMSE score in the experimental group was （28.34 ± 4.12） points, and the score of MMSE in the control group was （22.19 ± 5.49） points. The difference in the two groups has statistically significant （P〈0.05）. Conclusion The effect of cognitive dysfunction is better which ganglioside was used on the treatment of the patients with traumatic brain injury intraoperative and postoperative, and the cure rate is higher. It has the significance of further popularization and application.