喘息患儿与血清25-羟维生素D_3水平间相关性分析

Correlation between wheezing and serum 25-hydroxy vitamin D3 levels

目的 探讨喘息患儿与血清25-羟维生素D3水平间相关性。方法 选取温岭市妇幼保健院收治的130例下呼吸道感染患儿作为研究对象,其中喘息患儿为甲组（n=70）;普通肺炎（无喘息）者为乙组（n=60）;另选取同期于医院健康体检的健康儿童为对照组（n=60）。采用ELISA方法测定对照组及住院患儿入院当日血清25-羟维生素D3水平;同时检测甲乙2组患儿病原学及过敏原。结果 甲组、乙组血清25-羟维生素D3水平分别为（56.92±16.88）nmol/L、（70.68±21.96）nmol/L,明显低于对照组（82.69±17.63）nmol/L,（t=8.50,3.30;P=0.00,0.00）;甲乙组比较（t=3.85,P=0.00）。甲组病毒检测阳性率为65.71%,明显高于乙组（35.00%,χ^2=12.20,P=0.00）。甲组过敏原检查阳性率30.00%与对照组（35.00%）比较（χ^2=0.36,P=0.54）。甲组患儿血清25-羟维生素D3水平〈75 nmol/L率为88.57%,明显高于乙组（60.00%,χ^2=14.21,P=0.00）。血清25-羟维生素D3水平〈75 nmol/L的98例患儿中,其病毒检测阳性率为57.14%,明显高于血清25-羟维生素D3水平≥75 nmol/L患儿病毒检测阳性率（18.75%,χ^2=14.25,P=0.00）。血清25-羟维生素D3水平〈75 nmol/L患者中过敏原阳性率35.71%,明显高于血清25-羟维生素D3水平≥75 nmol/L患儿过敏原阳性率（21.88%,χ^2=2.11,P=0.14）。结论 喘息患儿的主要发病因素为病毒感染,而患儿血清25-羟维生素D3水平较低则会增加其病毒感染风险,从而致患者喘息发病风险增加,因此临床可通过检测儿童血清25-羟维生素D3水平来预测和干预儿童喘息的发生。

Objective To investigate the relationship between wheezing and serum levels of 25-hydroxyvitamin D3.Methods 130 children with lower respiratory tract infection were selected as the subjects, the children with wheezing in group A（[Abstract] Objective To investigate the relationship between wheezing and serum levels of 25-hydroxyvitamin D3.Methods 130 children with lower respiratory tract infection were selected as the subjects, the children with wheezing in group A（n=70）,normal pneumonia （no wheezing） were group B（n=60）; The healthy children who were examined in the hospital at the same period were selected as the control group （n=60）. The serum levels of 25-hydroxyvitamin D3 were measured by ELISA in the control and hospitalized children. The pathogens and allergens of the two groups were also detected. Results The levels of serum 25-hydroxyvitamin D3 in group A and group B were （56.92±16.88） nmol/L, （70.68±21.96） nmol/L, respectively, which was significantly lower than that in control group （82.69±17.63） nmol/L, （ t=8.50, 3.30,P=0.00,0.00）; compared with group A（ t=3.85, P=0.00）. The positive rate of group A was 65.71%, which was significantly higher than that of group B （35.00%, χ^2=12.20,P=0.00）. The positive rate of group A was 30.00% compared with the control group （35.00%, χ^2=0.36,P=0.54）. The serum level of 25-hydroxyvitamin D3 was 75.57% in group A, which was significantly higher than that in group B （60.00%,χ^2=14.21, P=0.00）. The positive rate of virus detection was 57.14% in 98 children with serum 25-hydroxy vitamin D3 level〈75 nmol/L, which was significantly higher than that in serum 25-hydroxy vitamin D3 level≥75 nmol/L（18.75%, χ^2=14.25, P=0.00）. The positive rate of allergens in serum 25-hydroxy vitamin D3 level 〈75 nmol/L was 35.71%, which was significantly higher than that in serum 25-hydroxy vitamin D3 level≥75 nmol/L（21.88%, χ^2=2.11, P=0.14）. Conclusion The main risk factor for children with wheezing is viral infection, while the low level of serum 25-hydroxy vitamin D3 in children increases the risk of viral infection, resulting in increased risk of wheezing in patients,so the clinical can occur through the detection of serum 25- hydroxyvitamin D3 levels to predict and intervention for children with wheezing.