代谢方对代谢综合征患者血脂异常、胰岛素抵抗的疗效观察

The intervention effect of Daixiefang on the patients of metabolic syndrome with dyslipidemia,insulin resistance

[目的]通过对代谢方干预代谢综合征患者血脂异常、胰岛素抵抗(痰瘀互阻型)的观察,以期阐述中药复方制剂在治疗代谢综合征伴有血脂异常及胰岛素抵抗的临床疗效及安全性。[方法]将符合中医辨证为痰瘀互阻证患者62例,随机分为代谢方治疗组21例,给予代谢方治疗;血脂康治疗组20例,给予血脂康片治疗;代谢方+血脂康组21例,给予代谢方+血脂康片治疗。疗程3个月。[结果]3组治疗均能明显降低代谢综合征痰瘀互阻证患者的血脂,改善中医证候及胰岛素抵抗,且中药代谢方联合血脂康治疗组疗效优于其他两组。各组治疗期间均未出现药物性肝肾损伤等明显不良反应。[结论]代谢方具有活血化瘀、健脾化痰之效,对代谢综合征痰瘀互阻证患者疗效显著。

[Objective] To evaluate the intervention effect and safety of Daixiefang, and to elaborate the advantages and prospects of compound traditional Chinese medicine preparation in the treatment of metabolic syndrome associated with dyslipidemia and insulin resistance （phlegm and blood stasis type）. [Methods] Sixty-two cases of metabolic syndrome patients associated with dyslipidemia were randomly divided into Daixiefang group, Xuezhikang group, and Daixiefang plus Xuezhikang group. The clinical effective rate, blood lipid, insulin resistance, pancreatic P-cell function, as well as integral of the symptoms were observed in three groups. In the end, it was established a database and analyzed the data by statistical software SPSS 21.0. [Results] No side-effect （liver and kidney damage） was found during the trail. Triglycerides, total cholesterol, LDL, Fasting glucose, Homa-IR of the three groups after treatment were reduced significantly （ P〈0.05） Daixiefang plus Xuezhikang group acted effectively on decreasing laboratory indicators than the other two groups. Integral of the symptoms of MS was also decreased significantly （ P〈0.05）. [Conclusion] Daixiefang plus Xuezhikang group is better than Xuezhikang group in lipids and symptoms. In summary, Daixiefang is effective in patients of MS with dyslipidemia.