新生儿低血糖对学龄前期儿童气质及行为发育的影响

Effects of neonatal hypoglycemia on temperament and neurobehavioral development of preschool children

目的新生儿低血糖症是新生儿期常见的代谢性疾病,少数患儿可出现神经系统后遗症。文中探讨新生儿低血糖症患儿在学龄前期的神经心理行为发育情况。方法采用中国学龄前儿童气质量表和Conners父母用症状问卷对安徽省儿童医院新生儿科自2009年3月至2013年5月期间35例确诊为新生儿低血糖症患儿(低血糖组)进行评估,同时收集纳入对象的围产期、临床资料以及家庭环境信息;同时随机抽取同期50例健康新生儿(对照组)进行对比研究。结果低血糖组与对照组儿童均主要为"易养型气质"和"中间偏易养型气质";低血糖组儿童的气质维度中趋避性与对照组比较差异有统计学意义(P<0.05);低血糖组儿童行为问题总检出率为24%,表现为学习问题和心身问题,与对照组儿童行为比较差异有统计学意义(P<0.05)。结论新生儿低血糖症影响学龄前期儿童的行为发育,应根据其气质和行为发育特点采取个体化的临床治疗和教育干预。

Objective Neonatal hypoglycemia is a common metabolic disease during neonatal period and a few children with neonatal hypoglycemiamay show a series of neurologic impairment. This study was to explore the neurobehavioral development of preschool children with neonatal hypoglycemia. Methods 37 children with neonatal hypoglycemia in Neonate Department of Anhui Provincal Children＇s Hospital from March 2009 to May 2013 were investigated by Chinese Preschool-Children Temperament Scale and Conners Symptoms Questionnaire for Parents,together with the information collection of perinatal period,clinical data and family environment. At the same time 50 controls were randomly chosed of the same period. Results The children of hypoglycemia group and control group were mainly with ＂ easy temperament＂ and ＂ inclined easy temperament＂. In the nine dimensions of temperament,there was statistical difference in approach-withdraw between two groups（P 0. 05）. The incidence of behavioral problem in hypoglycemia group is 24%,involving learning problem and psychophysical problem,and there were statistical difference between two groups in this aspect（P〈0.05）. Conclusion Neonatal hypoglycemia affects the neurobehavioral development of preschool children. Individualized treatment and education intervention should be taken according to the children＇s temperament and neurobehavioral development.