P-tau蛋白在颅脑损伤及相关神经退行性病中的研究进展

The latest progress of p-tau conformations in traumatic brain injury and relevant neurodegeneration

大脑神经纤维缠结(NFTs)是阿尔茨海默病(AD)的标志性病变之一,由磷酸化tau蛋白(p-tau)构成。最近在慢性创伤性脑病(CTE)患者中发现,其他神经退行性病中也具有神经纤维缠结(NFTs)的特点。tau蛋白病变是颅脑损伤(TBI)相关AD和CTE的病因,顺式p-tau蛋白是脑损伤后神经退行性病变的一个早期驱动因子。顺式p-tau蛋白可促使tau蛋白病理化,并且在人体中检测顺式p-tau蛋白可能提供全新的诊断方法及预后措施。此外,个体化的顺式p-tau蛋白抗体最终可能发展为一项治疗AD、TBI及CTE的全新方案。文章对tau蛋白在TBI及神经退行性病中的作用机制、顺式P-tau蛋白的形成、顺式tau蛋白化的作用及顺式p-tau抗体治疗进行综述。

One of the common hallmark lesions of Alzheimer＇s disease（AD） brains is neurofibrillary tangles（NFTs）,which are composed of phosphorylated tau protein（p-tau）. NFTs are also a defining feature of other neurodegenerative disorders and have recently been identified in the patients suffering from chronic traumatic encephalopathy（CTE）. Tau protein pathological change is the etiological factor of AD and CTE after traumatic brain injury（TBI）,and CIS p-tau is an early driving factor of neurodegeneration after brain injury. CIS p-tau can induce tau protein pathology,and the detection of CIS p-tau in human may provide new diagnostic methods and prognostic measures. Furthermore,the individualized cis p-tau antibody could ultimately be developed as a new treatment for AD,TBI and CTE. This article reviews the mechanism of tau protein in TBI and neurodegeneration,the formation of CIS P-tau protein,the role of cistauosis and the progress of CIS p-tau antibody therapy.