hs-CRP和HCY及CysC与冠心病的相关性分析

Correlation analysis of hs-CRP,HC and CysC with coronary heart disease

目的分析超敏C-反应蛋白(hs-CRP)、同型半胱氨酸(HCY)及胱抑素C(CysC)与冠心病的相关性。方法选取本院2015年5月至2017年3月收治的117例冠心病患者为研究对象,根据冠心病不同类型,将其分为3组,即39例稳定型心绞痛患者(SAP组),39例不稳定心绞痛患者(UAP组),39例急性心肌梗死(AMI组),并选择同期进行健康检查的39名健康者为(对照组)。对比4组人员的超敏C-反应蛋白、同型半胱氨酸及胱抑素C水平,并采用logistic回归分析hs-CRP、HCY及CysC与冠心病的相关性。结果稳定型心绞痛组、不稳定心绞痛组、急性心肌梗死组、对照组的hs-CRP、HCY及CysC水平差异具有统计学意义(P<0.05);排除其他影响因素,采用多元logistic回归分析对hs-CRP、HCY及CysC等指标进行统计学处理,发现影响冠心病发生的危险因素为hs-CRP、HCY及CysC(P<0.05)。结论 hs-CRP、HCY及CysC水平与冠心病相关,冠心病患者病情越严重,其hs-CRP、HCY及CysC水平越高。

Objective To analyze the correlation of high sensitivity C-reactive protein（hs-CRP）, homocysteine（HCY）, and cystatin C（CysC） with coronary heart disease. Methods A total of 117 patients with coronary heart disease admitted in our hospital from May 2015 to March 2017 were divided into three groups according to the different types of coronary heart disease, including 39 patients with stable angina pectoris（a SAP group）, 39 patients with unstable angina pectoris（a UAP group） and 39 patients with acute myocardial infarction（an AMI group）. Thirty-nine persons for health examinations were taken as a control group. The levels of hs-CRP, HCY and CysC in patients with coronary artery disease were measured. The logistic regression analysis was performed to analyze the correlation of hs-CRP, HCY and CysC with coronary heart disease. Results There were significant differences among four groups in hs-CRP, HCY and CysC（P〈0.05）. The logistic regression analysis results showed that the risk factors of coronary heart disease were hs-CRP, HCY and CysC（P〈0.05）. Conclusion The levels of hs-CRP, HCY and CysC are correlated with coronary heart disease. The severity of coronary heart disease is higher, and the hs-CRP, HCY and CysC levels are higher.